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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc6a8tm1.2Clar
targeted mutation 1.2, Joseph Clark
MGI:3522510
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Slc6a8tm1.2Clar/Y involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL MGI:4941778


Genotype
MGI:4941778
ot1
Allelic
Composition
Slc6a8tm1.2Clar/Y
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a8tm1.2Clar mutation (1 available); any Slc6a8 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal rearing, social preference, acoustic startle, and prepulse inhibition
• following contextual fear conditioning, mice exhibit reduced freezing compared with wild-type mice
• however, cued fear conditioning is normal
• mice spend less time attending a novel object in a short-term novel object recognition test compared with wild-type mice
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice
• mice exhibit an increase in activity along the periphery of a novel environment compared with wild-type mice
• during the first 5 minutes in a novel environment

homeostasis/metabolism
• in the brain, muscle, heart, testes, and serum
• however, kidney levels are normal
• in the prefrontal cortex, hippocampus, and neostriatum

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Creatine Deficiency Syndrome 1; CCDS1 300352 J:169472





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory