Mouse Genome Informatics
ot1
    Slc6a8tm1.2Clar/Y
involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal rearing, social preference, acoustic startle, and prepulse inhibition
• following contextual fear conditioning, mice exhibit reduced freezing compared with wild-type mice
• however, cued fear conditioning is normal
• mice spend less time attending a novel object in a short-term novel object recognition test compared with wild-type mice
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice
• mice exhibit an increase in activity along the periphery of a novel environment compared with wild-type mice
• during the first 5 minutes in a novel environment

homeostasis/metabolism
• in the brain, muscle, heart, testes, and serum
• however, kidney levels are normal
• in the prefrontal cortex, hippocampus, and neostriatum

growth/size/body

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Creatine Deficiency Syndrome 1; CCDS1 300352 J:169472