Mouse Genome Informatics
ot1
    Slc6a8tm1.2Clar/Y
involves: BALB/cJ * C57BL/6 * C57BL/6J * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
N
• mice exhibit normal rearing, social preference, acoustic startle, and prepulse inhibition (J:169472)
• following contextual fear conditioning, mice exhibit reduced freezing compared with wild-type mice (J:169472)
• however, cued fear conditioning is normal (J:169472)
• mice spend less time attending a novel object in a short-term novel object recognition test compared with wild-type mice (J:169472)
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice (J:169472)
• mice exhibit longer latency to finding a visible platform in a Morris water maze likely due to decreased swim speed compared with wild-type mice (J:169472)
• mice exhibit an increase in activity along the periphery of a novel environment compared with wild-type mice (J:169472)
• during the first 5 minutes in a novel environment (J:169472)

homeostasis/metabolism
• in the brain, muscle, heart, testes, and serum (J:169472)
• however, kidney levels are normal (J:169472)
• in the prefrontal cortex, hippocampus, and neostriatum (J:169472)

growth/size

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Creatine Deficiency Syndrome 1; CCDS1 300352 J:169472