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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Als2tm1Cai
targeted mutation 1, Huaibin Cai
MGI:3522476
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Als2tm1Cai/Als2tm1Cai involves: 129X1/SvJ * C57BL/6J MGI:3589591


Genotype
MGI:3589591
hm1
Allelic
Composition
Als2tm1Cai/Als2tm1Cai
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Als2tm1Cai mutation (1 available); any Als2 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• intraperitoneal injection of 35 mg/kg paraquat induced death in about 50% of homozygotes compared to 0% of control mice
• homozygotes are not as sensitive to paraquat-induced mortality as are Ccstm1Pcw homozygotes

growth/size/body
• body weight is normal in young mice but increased by 18% and 25% at 12 and 20 months of age, respectively, compared to wild-type littermates

behavior/neurological
• no significant change in the latency to fall from a rotating rod is seen between 9 and 20 months of age and in repeated trials over multiple days homozygotes do not perform better in the first trials of day compared to their performance in the last trial of the preceding day
• a decrease in locomotor activity is seen in a novel environment; however, gait, grip, muscle tone, and startle response are all normal and no decrease in spontaneous activity is seen in a Flex-Field apparatus
• homozygotes spend less time in the center of an open field and spend less time and make fewer visits to the open arms of an elevated plus maze
• at 12 and 20 months of age homozygotes display a decreased latency to fall from a rotating rod compared to wild-type littermates

homeostasis/metabolism
• intraperitoneal injection of 35 mg/kg paraquat induced death in about 50% of homozygotes compared to 0% of control mice
• homozygotes are not as sensitive to paraquat-induced mortality as are Ccstm1Pcw homozygotes
• increased sensitivity to paraquat-induced in vitro neuronal cell death is seen in homozygous mice compared to wild-type littermates

nervous system
N
• no significant changes in peripheral nerve conduction or electromyography and no gross neuropathological abnormalities are seen

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Amyotrophic Lateral Sclerosis 2, Juvenile; ALS2 205100 J:100336





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory