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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl21Psttm
past-time
MGI:3522308
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxl21Psttm/Fbxl21Psttm involves: BTBR * C57BL/6J MGI:5484575
hm2
 		Fbxl21Psttm/Fbxl21Psttm involves: C57BL/6J MGI:5484571
ht3
 		Fbxl21Psttm/Fbxl21+ C57BL/6J-Fbxl21Psttm/JtJ MGI:3522347
cx4
 		Fbxl21Psttm/Fbxl21Psttm
Fbxl3Ovtm/Fbxl3Ovtm 		involves: BTBR * C57BL/6J MGI:5484573
cx5
 		Fbxl21Psttm/Fbxl21Psttm
Tg(Per2-luc)1Jt/0 		involves: C57BL/6J MGI:5484572


Genotype
MGI:5484575
hm1
Allelic
Composition		 Fbxl21Psttm/Fbxl21Psttm
Genetic
Background		 involves: BTBR * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21Psttm mutation (1 available); any Fbxl21 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:194037 )
• period length is 22.77 hr




Genotype
MGI:5484571
hm2
Allelic
Composition		 Fbxl21Psttm/Fbxl21Psttm
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21Psttm mutation (1 available); any Fbxl21 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:194037 )
• shortened free running period




Genotype
MGI:3522347
ht3
Allelic
Composition		 Fbxl21Psttm/Fbxl21+
Genetic
Background		 C57BL/6J-Fbxl21Psttm/JtJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21Psttm mutation (1 available); any Fbxl21 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:91116 , J:194037 )
• short circadian free-running period in constant darkness (J:91116)




Genotype
MGI:5484573
cx4
Allelic
Composition		 Fbxl21Psttm/Fbxl21Psttm
Fbxl3Ovtm/Fbxl3Ovtm
Genetic
Background		 involves: BTBR * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21Psttm mutation (1 available); any Fbxl21 mutation (25 available)
Fbxl3Ovtm mutation (1 available); any Fbxl3 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:194037 )
N
• circadian period is 23.16 hr similar to that in wild-type controls and significantly shorter than the predicted 24.4 hr of an additive effect




Genotype
MGI:5484572
cx5
Allelic
Composition		 Fbxl21Psttm/Fbxl21Psttm
Tg(Per2-luc)1Jt/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21Psttm mutation (1 available); any Fbxl21 mutation (25 available)
Tg(Per2-luc)1Jt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hypothalamus physiology ( J:194037 )
• organotypic cultures of suprachiasmatic nucleus tissue and pituitary explants show robust rhythms with shortened periods

cellular
abnormal fibroblast physiology ( J:194037 )
• MEFs show advanced phases with short periods




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory