About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srftm1Rmn
targeted mutation 1, Narendrakumar Ramanan
MGI:3522206
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5659953
cn2
 		Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0 		involves: CD-1 MGI:3522658


Genotype
MGI:5659953
cn1
Allelic
Composition		 Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Srftm1Rmn mutation (1 available); any Srf mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:144862 )
• mice die at late embryonic stages

craniofacial
craniofacial phenotype ( J:144862 )
N
• tongue is present

cardiovascular system

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:144862 )
N
• external ear is present

immune system

skeleton

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:3522658
cn2
Allelic
Composition		 Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srftm1Rmn mutation (1 available); any Srf mutation (25 available)
Tg(Tagln-cre)1Jomm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:94725 )
• no viable embryos are found after E11.5

cardiovascular system
vascular smooth muscle hypotrophy ( J:94725 )
• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found
abnormal myocardial fiber morphology ( J:94725 )
• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed

muscle
vascular smooth muscle hypotrophy ( J:94725 )
• a 35% decrease in smooth muscle cells at the dorsal aspect of the aorta is found
abnormal myocardial fiber morphology ( J:94725 )
• the sarcomeres and Z disks are disorganized and the myofilaments are disarrayed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory