behavior/neurological

abnormal response to new environment ( J:125089 )

• in a novel area, mice are hypoactive, spend less time moving and travel shorter distances

• in an open field, mice rear more and spend more time exploring the center of an open field than wild-type mice

• mice display defective context-dependent learning relative to wild-type mice

increased startle reflex ( J:125089 )

hypoactivity ( J:125089 )

• in a novel area, mice are hypoactive, spend less time moving and travel shorter distances

increased vertical activity ( J:125089 )

• in an open field, mice rear more than wild-type mice

craniofacial

abnormal nasal bone morphology ( J:94405 )

• length and height at tip were statistically shorter

abnormal snout morphology ( J:94405 )

flattened snout ( J:94405 )

• flat to slightly concave snout sometimes curved to the right or left

short snout ( J:94405 )

• variably shorter snout often close to normal length

vision/eye

ocular hypertelorism ( J:94405 )

• more widely spaced eyes but distance variable, often near normal

growth/size

obese ( J:94405 )

• mice were significantly heavier than wild-type littermates at 10 weeks of age

skeleton

abnormal nasal bone morphology ( J:94405 )

• length and height at tip were statistically shorter

Mouse Models of Human Disease		OMIM ID	Ref(s)
Smith-Magenis Syndrome; SMS		182290	J:94405