Mouse Genome Informatics
ht1
    Del(11Cops3-Gid4)2Jrl/+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• in a novel area, mice are hypoactive, spend less time moving and travel shorter distances
• in an open field, mice rear more and spend more time exploring the center of an open field than wild-type mice
• mice display defective context-dependent learning relative to wild-type mice
• in an open field, mice rear more than wild-type mice
• in a novel area, mice are hypoactive, spend less time moving and travel shorter distances

craniofacial
• length and height at tip were statistically shorter
• flat to slightly concave snout sometimes curved to the right or left
• variably shorter snout often close to normal length

vision/eye
• more widely spaced eyes but distance variable, often near normal

growth/size/body
• flat to slightly concave snout sometimes curved to the right or left
• variably shorter snout often close to normal length
• mice were significantly heavier than wild-type littermates at 10 weeks of age

skeleton
• length and height at tip were statistically shorter

Mouse Models of Human Disease
OMIM IDRef(s)
Smith-Magenis Syndrome; SMS 182290 J:94405