About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmp13tm1.1Werb
targeted mutation 1.1, Zena Werb
MGI:3521938
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmp13tm1.1Werb/Mmp13tm1.1Werb involves: 129S2/SvPas MGI:3522358
cx2
Mmp13tm1.1Werb/Mmp13tm1.1Werb
Mmp9tm1Tvu/Mmp9tm1Tvu
involves: 129S2/SvPas * 129S6/SvEvTac MGI:3522359


Genotype
MGI:3522358
hm1
Allelic
Composition
Mmp13tm1.1Werb/Mmp13tm1.1Werb
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp13tm1.1Werb mutation (2 available); any Mmp13 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the hypertrophic zone is expanded in the tibia and metatarsals, at E17 and 1 week after birth, respectively, however by 12 weeks of age the size of the hypertrophic zone is similar to wild-type
• chondrocytes proliferate and differentiate normally but accumulate in the most terminally differentiated hypertrophic state
• establishment of the primary ossification centers is normal
• the amount of trabecular bone is increased in the tibia and metatarsals by 3 weeks or 1 week of age, respectively, however by 1 year of age the amount of trabecular bone was similar to wild-type
• the organization of the trabecular bone is also irregular




Genotype
MGI:3522359
cx2
Allelic
Composition
Mmp13tm1.1Werb/Mmp13tm1.1Werb
Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp13tm1.1Werb mutation (2 available); any Mmp13 mutation (33 available)
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

skeleton
• the front of ossification is similar to that seen in Mmp9 single homozygotes
• the normal columnar architecture is lost
• seen in the long bones, more severe than in either single homozygote
• development of the bone marrow cavity is delayed
• decreased trabecular bone formation and abnormal growth plate development result in dramatically shortened skeletal elements
• development of the secondary site of ossification is delayed





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory