Phenotypes associated with this allele

• Allele Symbol: Sat1^tm1Alh
• Allele Name: targeted mutation 1, Leena Alhonen
• Allele ID: MGI:3521903
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sat1^tm1Alh/Sat1^tm1Alh	B6.129X1-Sat1^tm1Alh	MGI:3709981
hm2	Sat1^tm1Alh/Sat1^tm1Alh	involves: 129X1/SvJ	MGI:3709982
cx3	Apc^Min/Apc^Min Sat1^tm1Alh/Y	involves: 129X1/SvJ * C57BL/6J	MGI:3709984

Genotype
MGI:3709981

hm1

• Allelic Composition: Sat1^tm1Alh/Sat1^tm1Alh
• Genetic Background: B6.129X1-Sat1^tm1Alh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:120870 )

♀ • females are infertile except at a very young age

adipose tissue

increased total fat pad weight ( J:120870 )

♀ • at 30 weeks mice fat pads weigh more, 670+/-107mg compared to 450+/-84mg in controls, despite no difference in body weight or eating habits

increased percent body fat/body weight ( J:120870 )

♀ • mice have a higher percent body fat at 12.7% compared to 8.9% in controls

abnormal white adipose tissue physiology ( J:120870 )

♀ • approximately 75% decrease in glucose oxidation in the liver slices and white adipose spreads

homeostasis/metabolism

increased circulating leptin level ( J:120870 )

♀ • serum leptin levels are increased at 3.9+/-0.74 compared to 2.74+/-0.02 in controls

cellular

abnormal aerobic respiration ( J:120870 )

♀ • approximately 75% decrease in glucose oxidation in the liver slices and white adipose spreads

growth/size/body

increased susceptibility to weight gain ( J:120870 )

♀ • mice on a high fat diet gain 22.8g compared to a 10g gain by control mice on the same diet

liver/biliary system

abnormal liver physiology ( J:120870 )

♀ • approximately 75% decrease in glucose oxidation in the liver slices and white adipose spreads

Genotype
MGI:3709982

hm2

• Allelic Composition: Sat1^tm1Alh/Sat1^tm1Alh
• Genetic Background: involves: 129X1/SvJ

normal phenotype

no abnormal phenotype detected ( J:99381 )

♀ • mice are viable, fertile and show no obvious phenotype under the conditions the study

Genotype
MGI:3709984

cx3

• Allelic Composition: Apc^Min/Apc^Min; Sat1^tm1Alh/Y
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

neoplasm

decreased tumor incidence ( J:99381 )

♂ • total tumor counts in small intestine were reduced by about 75% for both small and large tumors

♂ • however, there is no significant effect on colonic tumor number or size despite the fact that Sat1 over-expression increases tumor number about 6-fold