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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adcyap1tm1Clw
targeted mutation 1, Christopher S Colwell
MGI:3521845
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adcyap1tm1Clw/Adcyap1tm1Clw B6.129S4-Adcyap1tm1Clw MGI:5471630
hm2
Adcyap1tm1Clw/Adcyap1tm1Clw involves: 129S4/SvJae * C57BL/6 MGI:3521908


Genotype
MGI:5471630
hm1
Allelic
Composition
Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic
Background
B6.129S4-Adcyap1tm1Clw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1tm1Clw mutation (1 available); any Adcyap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice
• mutant mice exhibit a 30% reduction of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra following a single dose (10 mg/kg) of the insecticide paraquat, although total number of neurons is not reduced

immune system
• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

homeostasis/metabolism

hematopoietic system
• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

cellular




Genotype
MGI:3521908
hm2
Allelic
Composition
Adcyap1tm1Clw/Adcyap1tm1Clw
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1tm1Clw mutation (1 available); any Adcyap1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50-80% of the expected number of homozygotes are found at the time of genotyping

behavior/neurological
• the free running period is about 20 minutes shorter, however no difference in synchronization to a light dark cycle or responding to shifts in the light dark cycle are seen
• a significant shortening of the phase angle of entrainment is seen
• in constant dark, a significant reduction in the phase advance induced by a single discrete light treatment is seen when either bright or dim light is used
• increased wheel-running activity is seen with a 12:12 light:dark cycle





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory