Mouse Genome Informatics
hm1
    Adcyap1tm1Clw/Adcyap1tm1Clw
B6.129S4-Adcyap1tm1Clw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice
• mutant mice exhibit a 30% reduction of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra following a single dose (10 mg/kg) of the insecticide paraquat, although total number of neurons is not reduced

immune system
• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

homeostasis/metabolism

hematopoietic system
• a single dose (10 mg/kg) of the insecticide paraquat increased numbers of Th17 cells in both spleen and blood, but not in lymph nodes
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• induction of regulatory T cells is impaired in lymph nodes following administration of paraquat
• saline-treated mice exhibit an increase in number of large diameter microglia (activated) and a decrease in number of small diameter microglia (resting) as compared to saline-treated wild type; no significant changes are observed between paraquat-treated mutant and control mice

cellular


Mouse Genome Informatics
hm2
    Adcyap1tm1Clw/Adcyap1tm1Clw
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 50-80% of the expected number of homozygotes are found at the time of genotyping

behavior/neurological
• the free running period is about 20 minutes shorter, however no difference in synchronization to a light dark cycle or responding to shifts in the light dark cycle are seen
• a significant shortening of the phase angle of entrainment is seen
• in constant dark, a significant reduction in the phase advance induced by a single discrete light treatment is seen when either bright or dim light is used
• increased wheel-running activity is seen with a 12:12 light:dark cycle