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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdk2tm1Rhar
targeted mutation 1, Robert A Harris
MGI:3521813
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdk2tm1Rhar/Pdk2tm1Rhar B6.129-Pdk2tm1Rhar MGI:5009224
cn2
Pdk1tm1c(EUCOMM)Hmgu/Pdk1tm1c(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk3em1Eze/Pdk3em1Eze
Pdk4tm1Rhar/Pdk4tm1Rhar
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6J * C57BL/6N * SJL/J MGI:6712414
cn3
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6712415
cx4
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk3em1Eze/Pdk3em1Eze
Pdk4tm1Rhar/Pdk4tm1Rhar
involves: 129 * C57BL/6J * C57BL/6N MGI:6712416
cx5
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk4tm1Rhar/Pdk4tm1Rhar
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6712269


Genotype
MGI:5009224
hm1
Allelic
Composition
Pdk2tm1Rhar/Pdk2tm1Rhar
Genetic
Background
B6.129-Pdk2tm1Rhar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk2tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• at 40 Hz, muscle force is lower than in wild-type muscle




Genotype
MGI:6712414
cn2
Allelic
Composition
Pdk1tm1c(EUCOMM)Hmgu/Pdk1tm1c(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk3em1Eze/Pdk3em1Eze
Pdk4tm1Rhar/Pdk4tm1Rhar
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129 * C57BL/6J * C57BL/6N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1tm1c(EUCOMM)Hmgu mutation (0 available); any Pdk1 mutation (28 available)
Pdk2tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk3em1Eze mutation (0 available); any Pdk3 mutation (8 available)
Pdk4tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are viable

reproductive system
N
• mice are fertile

skeleton
N
• mice exhibit normal embryonic bone development




Genotype
MGI:6712415
cn3
Allelic
Composition
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1tm1a(EUCOMM)Hmgu mutation (0 available); any Pdk1 mutation (28 available)
Pdk2tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are viable

reproductive system
• mice are fertile

skeleton
• mice exhibit normal embryonic bone development




Genotype
MGI:6712416
cx4
Allelic
Composition
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk3em1Eze/Pdk3em1Eze
Pdk4tm1Rhar/Pdk4tm1Rhar
Genetic
Background
involves: 129 * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1tm1a(EUCOMM)Hmgu mutation (0 available); any Pdk1 mutation (28 available)
Pdk2tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk3em1Eze mutation (0 available); any Pdk3 mutation (8 available)
Pdk4tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between P0 and P4

homeostasis/metabolism
• at P1, but not E18.5
• increased serum 3-beta-hydroxybutyrate levels at P1, but not E18.5
• decreased pyruvate and lactate serum levels

skeleton
N
• mice exhibit normal embryonic bone development




Genotype
MGI:6712269
cx5
Allelic
Composition
Pdk1tm1a(EUCOMM)Hmgu/Pdk1tm1a(EUCOMM)Hmgu
Pdk2tm1Rhar/Pdk2tm1Rhar
Pdk4tm1Rhar/Pdk4tm1Rhar
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdk1tm1a(EUCOMM)Hmgu mutation (0 available); any Pdk1 mutation (28 available)
Pdk2tm1Rhar mutation (1 available); any Pdk2 mutation (23 available)
Pdk4tm1Rhar mutation (1 available); any Pdk4 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are viable

reproductive system
• mice are fertile

skeleton
• mice exhibit normal embryonic bone development





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory