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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc46a2tm1Moki
targeted mutation 1, Moon Kim
MGI:3521803
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc46a2tm1Moki/Slc46a2tm1Moki involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3812195
cx2
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
involves: 129 * C57BL/6 MGI:3812196


Genotype
MGI:3812195
hm1
Allelic
Composition
Slc46a2tm1Moki/Slc46a2tm1Moki
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc46a2tm1Moki mutation (0 available); any Slc46a2 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age

hematopoietic system
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age

endocrine/exocrine glands
• about one-third of mice have slightly lower thymic cell numbers at 6 weeks of age




Genotype
MGI:3812196
cx2
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Slc46a2tm1Moki/Slc46a2+
Tg(TcraB12,TcrbB12)1Rest/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (78 available)
Slc46a2tm1Moki mutation (0 available); any Slc46a2 mutation (2 available)
Tg(TcraB12,TcrbB12)1Rest mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
• double-positive T cells are absent in the thymus
• T cells are arrested in the DN3 stage

hematopoietic system
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice
• double-positive T cells are absent in the thymus
• T cells are arrested in the DN3 stage

cellular
• massive cell death of double negative as well as CD4+ and/or CD8+ thymocytes occur in these mice

endocrine/exocrine glands
• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice





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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory