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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnn4tm1Jemn
targeted mutation 1, James E Melvin
MGI:3521668
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnn4tm1Jemn/Kcnn4tm1Jemn involves: 129S1/Sv * C57BL/6J MGI:3527178


Genotype
MGI:3527178
hm1
Allelic
Composition
Kcnn4tm1Jemn/Kcnn4tm1Jemn
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnn4tm1Jemn mutation (2 available); any Kcnn4 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seen

hematopoietic system
• A23187-stimulated, clotrimazole sensitive uptake of 86Rb into red blood cells is nearly eliminated in homozygous mutants and A23187 has no effect on the tonicity at which 50% of mutant red cells lyse
• shrinkage of T lymphocytes induced by the Ca2+ ionophore, ionomycin, is greatly reduced

immune system
• shrinkage of T lymphocytes induced by the Ca2+ ionophore, ionomycin, is greatly reduced

digestive/alimentary system
• in homozygous males the weight of the parotid gland is significantly increased, however no change in salivary flow or composition is seen





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory