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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apctm1Cip
targeted mutation 1, Christine Perret
MGI:3513416
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apctm1Cip/Apctm1Cip involves: 129P2/OlaHsd * C57BL/6 MGI:3513847
ht2
Apctm1Cip/Apc+ involves: 129P2/OlaHsd * C57BL/6 MGI:3513849
cx3
Apctm1Cip/Apc+
H19tm1Lda/H19+
involves: 129P2/OlaHsd * 129S2/SvPas MGI:3845818
cx4
Apctm1Cip/Apc+
H19tm1Lda/H19+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:3845817
cx5
Apctm1Cip/Apc+
Nrip1tm1Mpk/Nrip1+
involves: 129P2/OlaHsd * C57BL/6J MGI:5574446


Genotype
MGI:3513847
hm1
Allelic
Composition
Apctm1Cip/Apctm1Cip
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no newborn homozygous pups are seen




Genotype
MGI:3513849
ht2
Allelic
Composition
Apctm1Cip/Apc+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 9% of heterozygotes developed mammary adenocanthomas

endocrine/exocrine glands
• 9% of heterozygotes developed mammary adenocanthomas

mortality/aging
• heterozygotes begin to die at 4 months of age with 50% dying by 6 months of age

neoplasm
• in situ carcinomas are seen in both the small and large intestines
• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas
• small and large adenomas are seen throughout the intestine
• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions
• compared to ApcMin heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines
• 9% of heterozygotes developed mammary adenocanthomas

cardiovascular system
• first seen around 4 months of age, associated with decreased life span

digestive/alimentary system
• first seen around 4 months of age, associated with decreased life span
• rectal prolapse, associated with more severe polyposis in the colon, is seen as early as 4 months of age and is seen in 61% of surviving mutants by 6 months of age
• the prolapse is highly dysplatic and in 10% of these dysplatic areas adenocarcinoma is also seen
• fewer mutants raised in specific pathogen-free conditions developed rectal prolapse
• in situ carcinomas are seen in both the small and large intestines
• over 50% of lesions in mutants over 12 months of age are tubular adenomas harboring invasive carcinomas
• small and large adenomas are seen throughout the intestine
• the number of polyps is increased and the distribution of polyps shifted towards the ileum under specific pathogen-free conditions
• compared to ApcMin heterozygotes more lesions are see in the colon, however the overall number of lesions is the same in both lines

hematopoietic system
• first seen around 4 months of age, associated with decreased life span




Genotype
MGI:3845818
cx3
Allelic
Composition
Apctm1Cip/Apc+
H19tm1Lda/H19+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (59 available)
H19tm1Lda mutation (1 available); any H19 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit a 1.4-fold increase in the number of adenomas compared to in Apctm1Cip heterozygotes




Genotype
MGI:3845817
cx4
Allelic
Composition
Apctm1Cip/Apc+
H19tm1Lda/H19+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (59 available)
H19tm1Lda mutation (1 available); any H19 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• some adenocarcinoma in situ in the intestines
• mice exhibit a 2.2-fold increase in the number of adenomas compared to in Apctm1Cip heterozygotes

digestive/alimentary system
• mice exhibit a 3-fold increase in the number of small polyps compared to in Apctm1Cip heterozygotes
• some adenocarcinoma in situ in the intestines




Genotype
MGI:5574446
cx5
Allelic
Composition
Apctm1Cip/Apc+
Nrip1tm1Mpk/Nrip1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (59 available)
Nrip1tm1Mpk mutation (0 available); any Nrip1 mutation (151 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compared with Apctm1Cip heterozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory