Analysis Tools
cardiovascular system
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• very mild in some mice
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nervous system
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• very mild in some mice
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Allele Symbol Allele Name Allele ID |
Tgfb1tm1Jmu targeted mutation 1, John Munger MGI:3513111 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very mild in some mice
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• very mild in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Tgfb1tm1Jmu/Tgfb1tm1Jmu mice develop fatal multiorgan inflammation
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• mice have reduced survival
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• while Mendelian ratios are present at E10.5, fewer than expected pups are born
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• between 18 and 28 days, marked mononuclear cell infiltration of multiple tissues, in particular, the heart, lung, liver, stomach, and pancreas and occasionally the central nervous system
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• inflammation lesions in the liver are localized to the portal canal
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• in the lung, inflammatory lesions are usually localized to bronchi and larger vessels and sometimes diffusely within the alveolar walls
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• at E10.5, yolk sacs lack normal vasculature
• at E12.5, yolk sac vasculature is not identifiable
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• at E10.5, yolk sacs have a variable paucity of vessels, absence of hemotopoietic cells and extensive buckling between the mesodermal and endodermal layer
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• at E10.5, yolk sacs have extensive buckling between the mesodermal and endodermal layer
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• at E10.5, yolk sacs are anemic or lacking normal vasculature
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• at day 14, mice are smaller in size
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• inflammation lesions in the liver are localized to the portal canal
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• in the lung, inflammatory lesions are usually localized to bronchi and larger vessels and sometimes diffusely within the alveolar walls
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• at E10.5, yolk sacs lack normal vasculature
• at E12.5, yolk sac vasculature is not identifiable
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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• phenotype is indistinguishable from that seen on a 129S6/SvEvTac C57BL/6 background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• while Mendelian ratios are present at E10.5, fewer than expected pups are born
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very few mice are born
• Background Sensitivity: fewer mice are born than on a background lacking BALB/c or containing ICR
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• in all mice
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• in all mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice only survive 3 weeks before dying of widespread inflammation
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• rarely
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• rarely
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: more mice are born on a background containing ICR than on a background containing BALB/c or lacking both ICR and BALB/c
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• all mice die within hours of birth
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• as early as E11.5
• at E13.5, brain vasculature exhibits extensive cavitation compared to in control mice
• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice
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• as early as E11.5
• severe by E15.5
• in all mice
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• associated with brain hemorrhage
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• enlarged ventricles
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• as early as E11.5
• at E13.5, brain vasculature exhibits extensive cavitation compared to in control mice
• in newborn mice, brain vessels are enlarged and hyperplastic compared to in control mice
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• as early as E11.5
• severe by E15.5
• in all mice
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• more extensive complete cleft of the secondary palate compared to in Tgfb3tm1Doe homozygotes on the same background
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| N |
• mice exhibit normal lung morphology
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• more extensive complete cleft of the secondary palate compared to in Tgfb3tm1Doe homozygotes on the same background
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• more extensive complete cleft of the secondary palate compared to in Tgfb3tm1Doe homozygotes on the same background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice only survive 3 weeks before dying of widespread inflammation
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• in newborn mice, brain vasculature exhibits cavitation compared to in control mice
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• in all newborn mice
• less severe than in double homozygotes
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• in newborn mice, brain vasculature exhibits cavitation compared to in control mice
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• in all newborn mice
• less severe than in double homozygotes
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• in newborn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die between E8.5 and E12.5
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• very few mice are born
• Background Sensitivity: more mice are born than on a background lacking BALB/c, but fewer mice are born than on a background containing ICR
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• in non-viable mice
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• in all mice
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• in non-viable mice
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• in all mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice only survive 3 weeks before dying of widespread inflammation
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• most mice die between E8.5 and E12.5
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• in non-viable mice
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• rarely
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• in non-viable mice
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• rarely
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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