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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brwd1repro5
reproductive mutant 5, JAX Reproductive Mutagenesis Program
MGI:3512929
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brwd1repro5/Brwd1repro5 involves: C3HeB/FeJ * C57BL/6J MGI:3512961
ht2
 		Brwd1Gt(AW0417)Wtsi/Brwd1repro5 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:3795359


Genotype
MGI:3512961
hm1
Allelic
Composition		 Brwd1repro5/Brwd1repro5
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brwd1repro5 mutation (0 available); any Brwd1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal oocyte morphology ( J:92463 )
• oocytes commonly contain vacuoles; oocytes have low developmental competence to 2-cell and blastocyst stages
necrospermia ( J:136078 )
• many sperm are dead
abnormal male germ cell morphology ( J:136078 )
• sperm cells exhibit post-meiotic defects such as round heads and bent flagellum
• however, meiosis progresses normally
oligozoospermia ( J:92463 )
• low epididymal sperm concentration
abnormal sperm flagellum morphology ( J:136078 )
• mutant sperm tails are often defective
abnormal sperm midpiece morphology ( J:136078 )
• some mutant sperm exhibit abnormal midpieces with a ragged or degenerated appearance
abnormal sperm head morphology ( J:136078 )
• >90% of mutant sperm exhibit a variety of abnormal head shapes vs <10% in wild type littermates
globozoospermia ( J:92463 , J:136078 )
• abnormal sperm head morphology (J:92463)
• sperm have abnormally shaped heads and acrosomes (J:136078)
abnormal female meiosis ( J:136078 )
• only 44% of oocytes progress to meiosis II
• inseminated meiosis II oocytes remain at the pronuclear stage and do not cleave
abnormal spermiogenesis ( J:92463 )
• impaired spermiogenesis
asthenozoospermia ( J:92463 , J:136078 )
• impaired sperm motility (J:92463)
(J:136078)
female infertility ( J:92463 , J:136078 )
(J:92463)
(J:136078)
male infertility ( J:92463 , J:136078 )
(J:92463)
(J:136078)
impaired fertilization ( J:136078 )
• epididymal sperm fail to fertilize wild-type oocytes in IVF experiments

cellular
abnormal oocyte morphology ( J:92463 )
• oocytes commonly contain vacuoles; oocytes have low developmental competence to 2-cell and blastocyst stages
necrospermia ( J:136078 )
• many sperm are dead
abnormal male germ cell morphology ( J:136078 )
• sperm cells exhibit post-meiotic defects such as round heads and bent flagellum
• however, meiosis progresses normally
oligozoospermia ( J:92463 )
• low epididymal sperm concentration
abnormal sperm flagellum morphology ( J:136078 )
• mutant sperm tails are often defective
abnormal sperm midpiece morphology ( J:136078 )
• some mutant sperm exhibit abnormal midpieces with a ragged or degenerated appearance
abnormal sperm head morphology ( J:136078 )
• >90% of mutant sperm exhibit a variety of abnormal head shapes vs <10% in wild type littermates
globozoospermia ( J:92463 , J:136078 )
• abnormal sperm head morphology (J:92463)
• sperm have abnormally shaped heads and acrosomes (J:136078)
asthenozoospermia ( J:92463 , J:136078 )
• impaired sperm motility (J:92463)
(J:136078)




Genotype
MGI:3795359
ht2
Allelic
Composition		 Brwd1Gt(AW0417)Wtsi/Brwd1repro5
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brwd1Gt(AW0417)Wtsi mutation (0 available); any Brwd1 mutation (106 available)
Brwd1repro5 mutation (0 available); any Brwd1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
globozoospermia ( J:136078 )
• sperm have abnormally shaped heads and acrosomes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 5-fold compared to in wild-type mice

cellular
globozoospermia ( J:136078 )
• sperm have abnormally shaped heads and acrosomes
decreased male germ cell number ( J:136078 )
• epididymal sperm are reduced more than 5-fold compared to in wild-type mice




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04/16/2024
MGI 6.23 		The Jackson Laboratory