Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
|
|
|
mortality/aging
cardiovascular system
|
• the paired dorsal aortas are small or undetectable and completely lack luminal blood at E9
|
|
• when visible the cardinal veins are devoid of luminal blood except at the point where it attaches to the sinus venosus
|
|
• endothelial cells are present but fail to form lumenized vessels
• in the aorta endothelial junctions are shortened
|
|
• fail to form lumenized vessels
|
|
• a dilated aortic sac is seen at E9
|
|
• blood cells are frequently detected in the pericardial cavity
|
embryo
homeostasis/metabolism
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
|
|
|
mortality/aging
|
• mice die between E9-E10 from failed angiogenesis
|
|
• no live-born homozygotes are observed; time of lethality not specified
|
cardiovascular system
|
• the caudal portion of the dorsal aorta becomes enlarged in 8.5 embryos
|
|
• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos
|
|
• the first branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the second branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the third branchial arch artery of E8.5 embryos fail to form a proper lumen
|
|
• adjacent portions of the aorta are narrow and irregular
|
|
• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos
• the heart is not functionally connected with the vasculature, and circulation fails to initiate
|
|
• E9.0 embryos fail to organize the yolk sac vasculature
|
|
• circulation is not established in E8.5 embryos
|
craniofacial
|
• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos
|
|
• the first branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the second branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the third branchial arch artery of E8.5 embryos fail to form a proper lumen
|
embryo
|
• E9.0 embryos fail to organize the yolk sac vasculature
|
|
• the branchial arch arteries, the first essential angiogenic vessels, fail to form a stable lumen in E8.5 embryos
|
|
• the first branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the second branchial arch artery of E8.5 embryos fails to form a proper lumen
|
|
• the third branchial arch artery of E8.5 embryos fail to form a proper lumen
|
|
• yolk sac vascular remodeling is abnormal in E8.5 embryos
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
|
|
|
cellular
|
• in heterozygous MEFs MAPK14 activation in response to hyperosmotic stress is reduced
|
Allelic Composition |
Ccm2Gt(RRG051)Byg/Ccm2+
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
|
|
|
Vascular malformations in the brains of Ccm2Gt(RRG051)Byg/Ccm2+ mice
cardiovascular system
|
• develop cerebral vascular malformations, including hemorrhaging, at low penetrance; clusters of blood vessels are similar to small cavernous malformations or capillary telangiectasias
|
nervous system
|
• develop cerebral vascular malformations, including hemorrhaging, at low penetrance; clusters of blood vessels are similar to small cavernous malformations or capillary telangiectasias
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
Ccm2ltm1Mlkn mutation
(0 available);
any
Ccm2l mutation
(14 available)
Heg1tm1Mlkn mutation
(0 available);
any
Heg1 mutation
(56 available)
|
|
|
mortality/aging
cardiovascular system
|
• about half exhibit normal cardiovascular development
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
Ccm2ltm1Mlkn mutation
(0 available);
any
Ccm2l mutation
(14 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
Heg1tm1Mlkn mutation
(0 available);
any
Heg1 mutation
(56 available)
|
|
|
mortality/aging
cardiovascular system
craniofacial
embryo
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2Gt(RRG051)Byg mutation
(0 available);
any
Ccm2 mutation
(47 available)
Heg1tm1Mlkn mutation
(0 available);
any
Heg1 mutation
(56 available)
|
|
|
mortality/aging
cardiovascular system
|
• the paired dorsal aortas are small or undetectable and completely lack luminal blood at E9
|
|
• when visible the cardinal veins are devoid of luminal blood except at the point where it attaches to the sinus venosus
|
|
• endothelial cells are present but fail to form lumenized vessels
|
|
• fail to form lumenized vessels
|
|
• a dilated aortic sac is seen at E9
|
|
• blood cells are frequently detected in the pericardial cavity
|
embryo
homeostasis/metabolism
growth/size/body