Mouse Genome Informatics
hm1
    Lgr5tm1Ah/Lgr5tm1Ah
involves: 129S5/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• phenotype is stated to be identical to that of Lgr5 tm1Ah homozygotes; however no data is presented in J:127123

behavior/neurological

growth/size

homeostasis/metabolism

respiratory system

digestive/alimentary system

craniofacial


Mouse Genome Informatics
hm2
    Lgr5tm1Ah/Lgr5tm1Ah
involves: 129S5/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• died within 24 hours after birth with empty stomachs filled with air

behavior/neurological
• stomachs were empty and filled with air presumably due to a suckling defect

growth/size
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible
• gradual distension of the abdomen after birth, so that by 12 hours after birth, the entire gastrointestinal tract became distended

homeostasis/metabolism
• mutants became gradually cyanotic with gasping respirations

respiratory system
• pressure against the diaphragm from the distended abdomen resulted in respiratory failure

digestive/alimentary system
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

craniofacial
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

Mouse Models of Human Disease
OMIM IDRef(s)
Ankyloglossia 106280 J:94196