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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lgr5tm1Ah
targeted mutation 1, Aaron Hsueh
MGI:3512420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lgr5tm1Ah/Lgr5tm1Ah involves: 129S5/SvEvBrd MGI:3764665
hm2
Lgr5tm1Ah/Lgr5tm1Ah involves: 129S5/SvEvBrd * C57BL/6 MGI:3512741


Genotype
MGI:3764665
hm1
Allelic
Composition
Lgr5tm1Ah/Lgr5tm1Ah
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1Ah mutation (0 available); any Lgr5 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• phenotype is stated to be identical to that of Lgr5 tm1Ah homozygotes; however no data is presented in J:127123

behavior/neurological

growth/size/body

homeostasis/metabolism

respiratory system

digestive/alimentary system

craniofacial




Genotype
MGI:3512741
hm2
Allelic
Composition
Lgr5tm1Ah/Lgr5tm1Ah
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1Ah mutation (0 available); any Lgr5 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died within 24 hours after birth with empty stomachs filled with air

behavior/neurological
• stomachs were empty and filled with air presumably due to a suckling defect

growth/size/body
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible
• gradual distension of the abdomen after birth, so that by 12 hours after birth, the entire gastrointestinal tract became distended

homeostasis/metabolism
• mutants became gradually cyanotic with gasping respirations

respiratory system
• pressure against the diaphragm from the distended abdomen resulted in respiratory failure

digestive/alimentary system
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

craniofacial
• tongue was fused along the entire ventral surface to the floor of the oral cavity and was attached to the mandible

Mouse Models of Human Disease
OMIM ID Ref(s)
Ankyloglossia 106280 J:94196





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory