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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prkar1atm1.2Lsk
targeted mutation 1.2, Lawrence Kirschner
MGI:3512112
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Tyr-cre)3Gfk/0
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:3580534
cn2
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Ghrhr-cre)3242Lsk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3771850


Genotype
MGI:3580534
cn1
Allelic
Composition
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Tyr-cre)3Gfk/0
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (0 available); any Prkar1a mutation (10 available)
Tg(Tyr-cre)3Gfk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• unilateral or bilateral tumors on the side of the face starting at 3 - 4 months

craniofacial
• unilateral or bilateral tumors on the side of the face starting at 3 - 4 months

nervous system
• tumors in subcutaneous tissue - Schwannomas

neoplasm
• unilateral or bilateral tumors on the side of the face starting at 3 - 4 months
• tumors in subcutaneous tissue - Schwannomas

Mouse Models of Human Disease
OMIM ID Ref(s)
Carney Complex, Type 1; CNC1 160980 J:98799




Genotype
MGI:3771850
cn2
Allelic
Composition
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Ghrhr-cre)3242Lsk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation (0 available); any Prkar1a mutation (10 available)
Tg(Ghrhr-cre)3242Lsk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)
• however, the number of prolactinomas is not increased relative to in wild-type mice
• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

endocrine/exocrine glands
• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)
• however, the number of prolactinomas is not increased relative to in wild-type mice
• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

neoplasm
• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)
• however, the number of prolactinomas is not increased relative to in wild-type mice
• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

homeostasis/metabolism
• regardless of tumor status mice exhibit increased serum growth hormone levels (28.27+/-41.4 ng/ml compared to 8.44+/-20.7 ng/ml in wild-type mice)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory