Mouse Genome Informatics
cn1
     Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Tyr-cre)3Gfk/0
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
increased facial tumor incidence ( J:98799 )
• unilateral or bilateral tumors on the side of the face starting at 3 - 4 months
increased Schwannoma incidence ( J:98799 )
• tumors in subcutaneous tissue - Schwannomas

Mouse Models of Human Disease
 OMIM IDRef(s)
Carney Complex, Type 1; CNC1 160980 J:98799


Mouse Genome Informatics
cn2
     Prkar1atm1.2Lsk/Prkar1atm1.2Lsk
Tg(Ghrhr-cre)3242Lsk/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
increased pituitary gland tumor incidence ( J:130264 )
• when pituitary glands are examined, mice exhibit an increased rate of tumorigenesis (in 48% of mice compared to 30.6% of wild-type mice)
• however, the number of prolactinomas is not increased relative to in wild-type mice
• nonprolactonmas stain positive for multiple hormone subtypes including Prl, GH and TSH

homeostasis/metabolism
increased circulating growth hormone level ( J:130264 )
• regardless of tumor status mice exhibit increased serum growth hormone levels (28.27+/-41.4 ng/ml compared to 8.44+/-20.7 ng/ml in wild-type mice)