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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ts(1716)65Dn
trisomy, Chr 16 translocation to Chr 17, Davisson 65
MGI:3512067
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Rcan1tm1Fmc/Rcan1+
Ts(1716)65Dn/0
involves: 129S4/SvJae * C3H/HeSn * C57BL/6 * C57BL/6Ei * DBA/2J MGI:3850820
cx2
Ts(1716)65Dn/Del(16Cbr1-Fam3b)1Rhr involves: 129S6/SvEvTac * C57BL/6 * DBA/2J MGI:3718058
cx3
Del(16App-Runx1)5Yah/Ts(1716)65Dn involves: BALB/c * C3H * C57BL/6 * DBA/2J MGI:5431228
ot4
Ts(1716)65Dn/0 B6EiC3Sn a/A-Ts(1716)65Dn/J MGI:3850819
ot5
Ts(1716)65Dn/0 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ MGI:4365946
ot6
Ts(1716)65Dn/0 involves: C3H * C57BL/6 * DBA/2J MGI:3831736
ot7
Ts(1716)65Dn/0 involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J MGI:5431229
ot8
Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6 * DBA/2J MGI:3718059
ot9
Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6J * DBA/2J MGI:5140734
ot10
Ts(1716)65Dn/0 involves: C3H/HeJ * C57BL/6JEi * DBA/2J MGI:3831747
ot11
Ts(1716)65Dn/0 involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J MGI:3703450
ot12
Ts(1716)65Dn/0 involves: DBA/2J MGI:3718084


Genotype
MGI:3850820
cx1
Allelic
Composition
Rcan1tm1Fmc/Rcan1+
Ts(1716)65Dn/0
Genetic
Background
involves: 129S4/SvJae * C3H/HeSn * C57BL/6 * C57BL/6Ei * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rcan1tm1Fmc mutation (0 available); any Rcan1 mutation (7 available)
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice but not as much as in Ts(1716)65Dn mice




Genotype
MGI:3718058
cx2
Allelic
Composition
Ts(1716)65Dn/Del(16Cbr1-Fam3b)1Rhr
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16Cbr1-Fam3b)1Rhr mutation (1 available); any Del(16Cbr1-Fam3b)1Rhr mutation (1 available)
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice perform similar to control mice in a Morris water maze with a visible or hidden platform

craniofacial
• mice have craniofacial dysmorpholgy that is similar to that seen in Ts(1716)65Dn mice




Genotype
MGI:5431228
cx3
Allelic
Composition
Del(16App-Runx1)5Yah/Ts(1716)65Dn
Genetic
Background
involves: BALB/c * C3H * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(16App-Runx1)5Yah mutation (0 available); any Del(16App-Runx1)5Yah mutation (0 available)
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are produced in the expected Mendelian ratio

cardiovascular system
• electrocardiogram phenotypes observed in Ts(1716)65Dn mice are partially rescued




Genotype
MGI:3850819
ot4
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
B6EiC3Sn a/A-Ts(1716)65Dn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transplanted Lewis lung and B16F10 tumor cells exhibit growth suppression with reduced microvessel density compared to tumor cells transplanted into wild-type mice

behavior/neurological
• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
• physical exercise improves performance of 12-13 month old mutants, but not controls, in the acquisition of the Morris water maze (J:170195)
• however, physical exercise has no effect on anxiety or depression behaviors in mutants (J:170195)
• output of a grip strength meter shows reduced grip force relative to controls
• significantly increased dark cycle rearing
• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
• significantly increased dark cycle horizontal and vertical stereotypic activity

growth/size/body
• the length from the nost to the tip of the tail and the length from the nose to the base of the tail are shorter than in background controls

nervous system
• mutants exhibit reduced cell proliferation and apoptosis in the hippocampus
• mutants exhibit a smaller subgranular zone
• exercise has no effect on the size of subgranular zone
• mutants exhibit a smaller dentate gyrus volume
• exercise has no effect on the size of dentate gyrus volume
• mutants exhibit reduced number of granule cells
• exercise has no effect on the number of granule cells
• hippocampal neurogenesis is reduced
• exercise has no effect on hippocampal neurogenesis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:170195




Genotype
MGI:4365946
ot5
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference

behavior/neurological
• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test
• output of a grip strength meter shows reduced grip force relative to controls
• significantly increased dark cycle rearing
• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls
• significantly increased dark cycle horizontal and vertical stereotypic activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:153579




Genotype
MGI:3831736
ot6
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice
• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice
• reduced in size compared to in wild-type mice
• reduced in size compared to in wild-type mice

skeleton
• mice exhibit a more generalized shortening of the skull along the anterior posterior axis compared to in Ts(1216)1Cje mice
• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice
• reduced in size compared to in wild-type mice
• reduced in size compared to in wild-type mice

growth/size/body
• mice exhibit a reduction in the height of the incisive alveolar segment compared to in wild-type mice




Genotype
MGI:5431229
ot7
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeH * C3H/HeSn * C57BL/6Ei * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cardiovascular abnormalities in Ts(1716)65Dn/0 mice

mortality/aging

cardiovascular system
• aberrant right subclavian artery arising from the distal part of the aortic arch
• great vessel and cardiac malformation in 1 of 18 mice that died postnatally
• 1 in 18 newborns exhibit an upper communication of the ventricles, indication a septation defect of the ventricles
• flecainide-treated mice exhibit a specific electrophysiologic signature as compare to wild-type mice
• in the frontal plane
• fragmented time-course with decreased S wave amplitude
• larger QT and QTc




Genotype
MGI:3718059
ot8
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeJ * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Purkinje cell density is reduced to 90% of that in control mice
• granule cell density is reduced to 76% of that in control mice
• cerebellar volume is reduced to 88% of that in control mice

behavior/neurological
• mice show impairment in a Morris water maze test

growth/size/body




Genotype
MGI:5140734
ot9
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• malignant lymphoma in the spleen and lymph nodes is observed in some mutants
• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia
• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma
• some mutants exhibit malignant tumors of liver, colon, or lung

immune system
• splenic red pulp is largely obliterated
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

hematopoietic system
• splenic red pulp is largely obliterated
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:174270




Genotype
MGI:3831747
ot10
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeJ * C57BL/6JEi * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Purkinje cell linear density is decreased compared to in wild-type mice




Genotype
MGI:3703450
ot11
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: C3H/HeSnJ * C57BL/6JEi * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• significantly more sperm with head abnormalities
• significantly reduced frequencies of sperm with progressive motility
• Leydig cells are clustered loosely in expanded interstitial compartment
• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
• testes are 37.9% of control testes weights (J:96650)
• significantly smaller testes than controls (J:117029)
• spermatocytes beyond pachytene stage and round spermatids are significantly reduced in number, while elongated spermatids are rare and remaining spermatids have deformed nuclei (J:96650)
(J:117029)
• sperm concentration was significantly reduced below controls
• many tubules contain germ cells in arrested at meiotic metaphase 1
• presence of an intact extra chromosome interferes with chromosome pairing in meiosis
• produced no progeny
• fail to produce a vaginal plug

cellular
• significantly more sperm with head abnormalities
• sperm concentration was significantly reduced below controls
• significantly reduced frequencies of sperm with progressive motility

growth/size/body
• mice are ~20% smaller in size compared to normal littermates postnatally

nervous system
• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
• the area of presynaptic elements (p38+) is increased in the fascia dentate and motor cortex
• in young and old mice alike, small presynaptic boutons are decreased and large presynaptic boutons are increased in the fascia dentate and motor cortex with the average diameter of a presynaptic bouton increased by 40% in the cortex
• 18% of dendritic spines are enlarged and display irregular heads or a globular shape
• average synapse length is increased 34% in the hippocampus and 25% in the cortex
• glutamatergic synapses are distributed 33% on the dendritic shaft (compared to 51% in wild-type mice) and 67% (compared to 49% in wild-type mice) on the heads or necks of the dendritic spines
• in fascia dentate, spine density is significantly decreased on dendrites of granule cells; dendritic spines are significantly enlarged; dendritic width is similar to controls
• dendritic spine density on granule cells is decreased on average by 17% compared to in wild-type mice
• 18% of spines are enlarged and display irregular heads or a globular shape
• basal dentritic spine density in CA1 is increased

endocrine/exocrine glands
• Leydig cells are clustered loosely in expanded interstitial compartment
• only a few Sertoli cells are visible; germ cells appear to be detached from the remaining Sertoli cells
• testes are 37.9% of control testes weights (J:96650)
• significantly smaller testes than controls (J:117029)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Down syndrome DOID:14250 OMIM:190685
J:94569 , J:96650




Genotype
MGI:3718084
ot12
Allelic
Composition
Ts(1716)65Dn/0
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ts(1716)65Dn mutation (2 available); any Ts(1716)65Dn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• size difference was most pronounced along the rostralcaudal axis
• cranial vault is enlarged
• mice show a Down's Syndrome-like pattern of mandible reduction

limbs/digits/tail

skeleton
• size difference was most pronounced along the rostralcaudal axis
• cranial vault is enlarged
• mice show a Down's Syndrome-like pattern of mandible reduction





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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory