hm1

Ddb2^tm1Pra/Ddb2^tm1Pra
involves: C57BL/6

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

premature death ( J:95633 )

• 100% died between 20 and 26 months of age

tumorigenesis

increased tumor incidence ( J:95633 )

• high susceptibility to UV induced tumor incidence

• develop very aggressive tumors, death occurs within 3 weeks of tumor development

• broad spectrum of tumors found in mice dying between 20 and 26 months of age

Mouse Models of Human Disease		OMIM ID	Ref(s)
Xeroderma Pigmentosum, Complementation Group E		278740	J:95633

ht2

Ddb2^tm1Pra/Ddb2⁺
involves: C57BL/6

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

premature death ( J:95633 )

• 70% (7 of 10) died between 20 and 26 months of age

tumorigenesis

increased tumor incidence ( J:95633 )

• broad spectrum of tumors found in mice dying between 20 and 26 months of age

• 3 of 7 dead mice had tumors of varying types

Mouse Models of Human Disease		OMIM ID	Ref(s)
Xeroderma Pigmentosum, Complementation Group E		278740	J:95633