About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddb2tm1Pra
targeted mutation 1, Pradip Raychaudhuri
MGI:3511965
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddb2tm1Pra/Ddb2tm1Pra involves: C57BL/6 MGI:3512004
ht2
Ddb2tm1Pra/Ddb2+ involves: C57BL/6 MGI:3512005


Genotype
MGI:3512004
hm1
Allelic
Composition
Ddb2tm1Pra/Ddb2tm1Pra
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2tm1Pra mutation (0 available); any Ddb2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% died between 20 and 26 months of age

neoplasm
• broad spectrum of tumors found in mice dying between 20 and 26 months of age
• high susceptibility to UV induced tumor incidence
• develop very aggressive tumors, death occurs within 3 weeks of tumor development

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:95633




Genotype
MGI:3512005
ht2
Allelic
Composition
Ddb2tm1Pra/Ddb2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2tm1Pra mutation (0 available); any Ddb2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% (7 of 10) died between 20 and 26 months of age

neoplasm
• broad spectrum of tumors found in mice dying between 20 and 26 months of age
• 3 of 7 dead mice had tumors of varying types

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:95633





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory