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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddb2tm1Pra
targeted mutation 1, Pradip Raychaudhuri
MGI:3511965
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ddb2tm1Pra/Ddb2tm1Pra involves: C57BL/6 MGI:3512004
ht2
Ddb2tm1Pra/Ddb2+ involves: C57BL/6 MGI:3512005


Genotype
MGI:3512004
hm1
Allelic
Composition
Ddb2tm1Pra/Ddb2tm1Pra
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2tm1Pra mutation (0 available); any Ddb2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% died between 20 and 26 months of age (J:95633)
• 100% died between 20 and 26 months of age (J:95633)

tumorigenesis
• broad spectrum of tumors found in mice dying between 20 and 26 months of age (J:95633)
• high susceptibility to UV induced tumor incidence (J:95633)
• develop very aggressive tumors, death occurs within 3 weeks of tumor development (J:95633)
• broad spectrum of tumors found in mice dying between 20 and 26 months of age (J:95633)
• high susceptibility to UV induced tumor incidence (J:95633)
• develop very aggressive tumors, death occurs within 3 weeks of tumor development (J:95633)

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:95633




Genotype
MGI:3512005
ht2
Allelic
Composition
Ddb2tm1Pra/Ddb2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddb2tm1Pra mutation (0 available); any Ddb2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% (7 of 10) died between 20 and 26 months of age (J:95633)
• 70% (7 of 10) died between 20 and 26 months of age (J:95633)

tumorigenesis
• broad spectrum of tumors found in mice dying between 20 and 26 months of age (J:95633)
• 3 of 7 dead mice had tumors of varying types (J:95633)
• broad spectrum of tumors found in mice dying between 20 and 26 months of age (J:95633)
• 3 of 7 dead mice had tumors of varying types (J:95633)

Mouse Models of Human Disease
OMIM ID Ref(s)
Xeroderma Pigmentosum, Complementation Group E 278740 J:95633





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory