All Phenotypes Fcgrt<tm1Dcr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fcgrt^tm1Dcr
targeted mutation 1, Derry C Roopenian
MGI:3511510

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr	B6.129X1-Fcgrt^tm1Dcr/DcrJ	MGI:4441043
hm2	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr	either: 129 or (involves: 129 * C57BL/6)	MGI:3511521
cx3	Alb^em12Mvw/Alb^em12Mvw Fcgrt^tm1Dcr/Fcgrt^tm1Dcr Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr	B6.Cg-Tg(FCGRT)32Dcr Alb^em12Mvw Fcgrt^tm1Dcr/MvwJ	MGI:5608908
cx4	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr X/Yaa	BXSB.129X1-Fcgrt^tm1Dcr/Dcr	MGI:6094246
cx5	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4441042

Allelic Composition	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr
Genetic Background	B6.129X1-Fcgrt^tm1Dcr/DcrJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrt^tm1Dcr mutation (22 available); any Fcgrt mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating serum albumin level ( J:110885 )

immune system

decreased IgG level ( J:110885 )

hematopoietic system

decreased IgG level ( J:110885 )

Allelic Composition	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr
Genetic Background	either: 129 or (involves: 129 * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrt^tm1Dcr mutation (22 available); any Fcgrt mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgG level ( J:94189 )

• failure of perinatal IgG from mothers to newborns

• levels of maternal IgGs lowered in homozygous pups about 190 fold

• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days

• specific IgG memory response to antigen challenge is significantly reduced

hematopoietic system

decreased IgG level ( J:94189 )

• failure of perinatal IgG from mothers to newborns

• levels of maternal IgGs lowered in homozygous pups about 190 fold

• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days

• specific IgG memory response to antigen challenge is significantly reduced

Allelic Composition	Alb^em12Mvw/Alb^em12Mvw Fcgrt^tm1Dcr/Fcgrt^tm1Dcr Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic Background	B6.Cg-Tg(FCGRT)32Dcr Alb^em12Mvw Fcgrt^tm1Dcr/MvwJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alb^em12Mvw mutation (2 available); any Alb mutation (91 available)
Fcgrt^tm1Dcr mutation (22 available); any Fcgrt mutation (60 available)
Tg(FCGRT)32Dcr mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating serum albumin level ( J:101977 )

• mice lack albumin protein in their blood

Allelic Composition	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr X/Yaa
Genetic Background	BXSB.129X1-Fcgrt^tm1Dcr/Dcr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrt^tm1Dcr mutation (22 available); any Fcgrt mutation (60 available)
Yaa mutation (18 available); any Yaa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179430 )

• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males

Allelic Composition	Fcgrt^tm1Dcr/Fcgrt^tm1Dcr Tg(CAG-FCGRT)276Dcr/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrt^tm1Dcr mutation (22 available); any Fcgrt mutation (60 available)
Tg(CAG-FCGRT)276Dcr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating serum albumin level ( J:110885 )

immune system

immune system phenotype ( J:110885 )

N	• IgG levels are normalized

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