Mouse Genome Informatics
tg1
    Tg(Ela1-Myc)159Bri/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mutants die between 2 and 7 months of age

tumorigenesis
• 1 of 10 mutants exhibit tumors that spread to peritoneal surfaces or the liver
• mutants develop pancreatic tumors; tumor progression begins with a thickening of the pancreas at 1 month of age, the then development of 1-10 firm pale small pancreatic nodules at 1-4 months of age, and excessive tumor burden leading to death begins at 2 months of age
• during tumor development, acinar-like cells eventually replace islet tissue and eventually neoplastic ductal elements arise within acinar cell tumors to progress into mixed or ductal adenocarcinomas
• about 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas
• focal areas of some tumors exhibit squamous metaplasia or adenosquamous carcinoma
• tumors are frequently associated with inflammatory cell infiltrate
• about 50% of tumors exhibit characteristics of acinar cell carcinomas, the remaining 50% of tumors are mixed acinar/ductal pancreatic adenocarcinomas

liver/biliary system
• some mutants are jaundiced

endocrine/exocrine glands
• non-tumor portions of the pancreas appear atrophied
• small pancreas in some mutants

digestive/alimentary system
• non-tumor portions of the pancreas appear atrophied

Mouse Models of Human Disease
OMIM IDRef(s)
Pancreatic Cancer 260350 J:76992