Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr4tm1Cxd mutation
(0 available);
any
Fgfr4 mutation
(39 available)
Tg(Myl2-FGF19)1Dfre mutation
(0 available)
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neoplasm
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• the hepatocarcinogenesis observed in diethylnitrosamine (DEN) treated single Tg(Myl2-FGF19)1Dfre mutants is abolished in double mutants
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• mutants do not develop gross or histological evidence of hepatocellular neoplasia unlike single Tg(Myl2-FGF19)1Dfre mutant mice which develop hepatocellular carcinoma
• the preneoplastic hepatocellular proliferation that is seen in single Tg(Myl2-FGF19)1Dfre mutants is not evident in double mutants
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homeostasis/metabolism
liver/biliary system
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• mutants do not develop gross or histological evidence of hepatocellular neoplasia unlike single Tg(Myl2-FGF19)1Dfre mutant mice which develop hepatocellular carcinoma
• the preneoplastic hepatocellular proliferation that is seen in single Tg(Myl2-FGF19)1Dfre mutants is not evident in double mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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muscle
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• muscles of mutants have reduced triglyceride levels
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growth/size/body
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• mutants weight less than controls when fed a standard chow diet, with a significant difference in weight for males at 5 days of age and at 31 days of age for females
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• males and females are protected from high fat diet obesity, with fat pads weighting less than those from controls and exhibit lower leptin levels
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adipose tissue
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• interscapular brown adipose tissue depot is enlarged, however it appears histologically normal
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• reduction in fat content
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behavior/neurological
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• increase in total food intake
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homeostasis/metabolism
liver/biliary system
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• by 2-4 months of age, pericentral hepatocytes exhibit increased cell proliferation; proliferation is higher in females than males
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• mutants older then 5 months exhibit dysplastic changes in the liver
(J:76323)
• mutants exhibit dysplastic changes in the liver by 7-9 months of age; 33% of females and 7% of males show hepatocellular dysplasia without neoplasia within this age range
(J:77160)
• dysplastic foci are predominately of the small-cell type and oriented around central veins
(J:77160)
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• mutants fed either a low or a high fat diet have reduced liver triglyceride levels
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• 53% of mutants develop liver tumors by 10-12 months of age
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• 80% of females and 22% of males exhibit locally invasive hepatocellular carcinoma at 10-12 months of age
(J:77160)
• tumors are solitary or multifocal, involving different liver lobes
(J:77160)
• hepatocellular carcinomas are predominately the solid type although sometimes a trabecular pattern is seen
(J:77160)
• tumors do not metastasize
(J:77160)
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cellular
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• by 2-4 months of age, pericentral hepatocytes exhibit increased cell proliferation; proliferation is higher in females than males
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neoplasm
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• administration of diethylnitrosamine (DEN), a liver carcionogen, accelerates the development of hepatocellular carcinoma (HCC), such that aggressive HCC is seen by 4 months of age
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• 53% of mutants develop liver tumors by 10-12 months of age
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• 80% of females and 22% of males exhibit locally invasive hepatocellular carcinoma at 10-12 months of age
(J:77160)
• tumors are solitary or multifocal, involving different liver lobes
(J:77160)
• hepatocellular carcinomas are predominately the solid type although sometimes a trabecular pattern is seen
(J:77160)
• tumors do not metastasize
(J:77160)
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