About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Traf3ip2tm1.1Lix
targeted mutation 1.1, Xiaoxia Li
MGI:3510784
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix B6.129-Traf3ip2tm1.1Lix MGI:5440213
hm2
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix C.129-Traf3ip2tm1.1Lix MGI:5439184
hm3
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix involves: 129/Sv * BALB/c MGI:3511165
cn4
Traf3ip2tm1Lix/Traf3ip2tm1.1Lix
Tg(CD19-cre/ERT2)1Cgn/0
involves: 129/Sv * BALB/c MGI:3511174
cx5
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom MGI:5440219
cx6
Cd40tm1Kik/Cd40tm1Kik
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
involves: 129 * 129P2/OlaHsd * BALB/c MGI:3511170
cx7
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Tnfsf13btm1Msc/Tnfsf13btm1Msc
involves: 129 * 129S2/SvPas * BALB/c MGI:3511169


Genotype
MGI:5440213
hm1
Allelic
Composition
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
B6.129-Traf3ip2tm1.1Lix
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• Background Sensitivity: while mutants on the C57BL/6 background develop lupus-like disease, they fail to develop Sjogrens syndrome-like disease as seen in the BALB/c background, showing no signs of enlarged submaxillary glands or elevated serum anti-SSB/La IgG autoantibodies
• mutants exhibit a skewing in the repertoire from T1 to T2/T3 B cells resulting in ratios of T2:T1 and T3:T1 B cells that are increased compared to wild-type mice
• number of B cells in the spleen shows a trend toward a statistical increase compared to controls
• however, number of T cells in the spleen is similar to wild-type
• 16-18 week old mutants exhibit significantly increased numbers of total immature AA4.1+B220+ B cells
• mutants exhibit elevated levels of marginal zone B cells
• however, no increase in the number of follicular mature B cells is seen
• in 32-40 week old mutants
• in 32-40 week old mutants
• in 32-40 week old mutants
• 28-32 week old mutants exhibit hypergammaglobulinemia
• however levels of IgM are normal
• increase in cervical lymph node weight and cellularity in 32-40 week old mutants
• increase in cervical lymph node weight and cellularity in 32-40 week old mutants
• 28-32 week old mutants exhibit elevated levels of serum anti-nuclear autoantibodies (anti-chromatin IgG, anti-histone IgG, and anti-dsDNA IgG)

hematopoietic system
• mutants exhibit a skewing in the repertoire from T1 to T2/T3 B cells resulting in ratios of T2:T1 and T3:T1 B cells that are increased compared to wild-type mice
• number of B cells in the spleen shows a trend toward a statistical increase compared to controls
• however, number of T cells in the spleen is similar to wild-type
• 16-18 week old mutants exhibit significantly increased numbers of total immature AA4.1+B220+ B cells
• mutants exhibit elevated levels of marginal zone B cells
• however, no increase in the number of follicular mature B cells is seen
• in 32-40 week old mutants
• in 32-40 week old mutants
• in 32-40 week old mutants
• 28-32 week old mutants exhibit hypergammaglobulinemia
• however levels of IgM are normal

renal/urinary system
• mutants exhibit elevated IgG deposition within the kidney glomeruli
• however, renal failure is not seen in mutants up to 12 months of age
• kidneys show occasional obstruction of the capillary lumina
• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease

cardiovascular system
• kidneys show occasional obstruction of the capillary lumina

Mouse Models of Human Disease
OMIM ID Ref(s)
Systemic Lupus Erythematosus; SLE 152700 J:187766




Genotype
MGI:5439184
hm2
Allelic
Composition
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
C.129-Traf3ip2tm1.1Lix
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die around 4 months of age and by 12 months of age, about 83% mutants are dead

immune system
• lymph nodes proximal to the submaxillary glands are greatly enlarged
• mutants, but not wild-type mice, develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens
• lymphocyte infiltration in lacrimal, parotid and submaxillary glands; most infiltrates are in the perivascular or periductal areas of the glands
• lymphocyte infiltration in parotid glands
• lymphocyte infiltration in submandibular glands
• lacrimal glands are infiltrated by B220+ B cells and T cells
• lymphocyte infiltration in lacrimal glands
• some mutants develop skin lesions around the eyes due to excessive scratching of affected eyes
• both males and females exhibit difficulties in maintaining fully opened eyelids beginning around 3 weeks of age due to inflammation
• mutants at 8-12 months of age exhibit lymphocyte infiltration in the kidney, including the glomeruli
• presence of anti-DNA autoantibodies and IgG complex in glomeruli, indicating development of glomerulonephritis

digestive/alimentary system
• mutants exhibit reduced flow rate of saliva production
• enlarged submaxillary glands
• lymphocyte infiltration in parotid glands
• lymphocyte infiltration in submandibular glands

renal/urinary system
• mutants at 8-12 months of age exhibit lymphocyte infiltration in the kidney, including the glomeruli
• presence of anti-DNA autoantibodies and IgG complex in glomeruli, indicating development of glomerulonephritis

craniofacial
• mouth inflammation
• mutants exhibit reduced flow rate of saliva production

endocrine/exocrine glands
• mutants exhibit reduced flow rate of saliva production
• lymphocyte infiltration in parotid glands
• lymphocyte infiltration in submandibular glands
• exocrine glands are infiltrated by large number of B and T cells
• enlarged submaxillary glands
• lymphocyte infiltration in lacrimal glands
• lacrimal glands are infiltrated by B220+ B cells and T cells

hematopoietic system

vision/eye
• lymphocyte infiltration in lacrimal glands
• lacrimal glands are infiltrated by B220+ B cells and T cells
• some mutants develop skin lesions around the eyes due to excessive scratching of affected eyes
• both males and females exhibit difficulties in maintaining fully opened eyelids beginning around 3 weeks of age due to inflammation

homeostasis/metabolism
• mutants exhibit reduced flow rate of saliva production

growth/size/body
• mouth inflammation
• mutants exhibit reduced flow rate of saliva production

Mouse Models of Human Disease
OMIM ID Ref(s)
Sjogren Syndrome 270150 J:138560




Genotype
MGI:3511165
hm3
Allelic
Composition
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
involves: 129/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the number of dendritic cells is increased in the spleen
• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates
• the density of B cell zones is increased
• IgG subclasses except for IgG3 are increased
• both T cell dependent and independent antigens elicit increased antigen-specific responses

immune system
• the number of dendritic cells is increased in the spleen
• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates
• the density of B cell zones is increased
• at 3 weeks of age the lymph nodes are enlarged from lymphoid hyperplasia, increased germinal centers, and accumulation of plasma cells
• IgG subclasses except for IgG3 are increased
• both T cell dependent and independent antigens elicit increased antigen-specific responses
• anti-dsDNA IgG antibodies are detected
• anti-histone IgG antibodies are detected
• anti-ssDNA IgG antibodies are detected
• inflammation is seen in multiple tissues including the skin
• upper respiratory airway inflammation is seen

respiratory system
• upper respiratory airway inflammation is seen




Genotype
MGI:3511174
cn4
Allelic
Composition
Traf3ip2tm1Lix/Traf3ip2tm1.1Lix
Tg(CD19-cre/ERT2)1Cgn/0
Genetic
Background
involves: 129/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
Traf3ip2tm1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the number of dendritic cells is increased in the spleen, this is less severe than in Act1 null mice
• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates
• this is less severe than in Act1 null mice
• this is less severe than in Act1 null mice
• this is less severe than in Act1 null mice

immune system
• the number of dendritic cells is increased in the spleen, this is less severe than in Act1 null mice
• the total splenic B cell population is increased however the proportions of different B cell stages are the same as in wild-type littermates
• this is less severe than in Act1 null mice
• this is less severe than in Act1 null mice
• this is less severe than in Act1 null mice
• this is less severe than in Act1 null mice




Genotype
MGI:5440219
cx5
Allelic
Composition
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
B6.129-Tcrbtm1Mom Traf3ip2tm1.1Lix Tcrdtm1Mom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (77 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (13 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• triple mutants exhibit reduced lupus-like phenotypes compared to Traf3ip2 single homozygotes, with normal spleen weight and cellularity, normal B cell numbers (B cell numbers however are decreased compared to Tcrb and Tcrd double homozygous mutants), normal cervical lymph node weight and cellularity, significantly less total IgG antibodies and anti-nuclear antigen specific IgG autoantibodies, and no IgG deposition in the kidney glomeruli
• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes
• serum levels of anti-chromatin IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
• serum levels anti-dsDNA IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes
• serum levels of anti-histone IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes

hematopoietic system
• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells
• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice
• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels
• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes
• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes
• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants
• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes

cardiovascular system
• kidneys show occasional obstruction of the capillary lumina

renal/urinary system
• mutants exhibit elevated levels of IgM deposition within kidney glomeruli
• kidneys show occasional obstruction of the capillary lumina
• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease




Genotype
MGI:3511170
cx6
Allelic
Composition
Cd40tm1Kik/Cd40tm1Kik
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic
Background
involves: 129 * 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Kik mutation (10 available); any Cd40 mutation (21 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants

immune system
N
• double mutants do not exhibit production of anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, as seen in Traf3ip2 single homozygotes
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• double mutants exhibit an increase in peripheral B cell populations compared to Cd40 single homozygotes
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
• Tnfsf13b (BAFF) stimulation results in enhanced B cell survival compared to single Cd40 mutants
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Immunodeficiency with Hyper-IgM, Type 1; HIGM1 308230 J:93923




Genotype
MGI:3511169
cx7
Allelic
Composition
Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic
Background
involves: 129 * 129S2/SvPas * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (13 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
• total number of mature B cells is reduced
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes

immune system
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
• total number of mature B cells is reduced
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes
• mutants develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, although to a lower level than in Traf3ip2 single homozygotes due to the low number of B cells, but higher levels than in Tnfsf13b single homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory