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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APPSL)28Lpr
transgene insertion 28, Laurent Pradier
MGI:3510606
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
either: 129/Sv or (involves: 129/Sv * C57BL/6) MGI:3510652
cx2
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
involves: 129 * C57BL/6 * CBA MGI:5003501
cx3
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0
involves: C57BL/6 * CBA MGI:5003459
tg4
Tg(Thy1-APPSL)28Lpr/0 B6.Cg-Tg(Thy1-APPSL)28Lpr MGI:5003504
tg5
Tg(Thy1-APPSL)28Lpr/0 involves: C57BL/6 * CBA MGI:5003460


Genotype
MGI:3510652
cx1
Allelic
Composition
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
either: 129/Sv or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Lpr mutation (0 available); any Psen1 mutation (28 available)
Tg(Thy1-APPSL)28Lpr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques
• marked reduction in thickness of the hippocampal pyramidal cell layer by 10 months of age
• no amyloid plaques in the CA1/2 pyramidal cell layer

homeostasis/metabolism
• accelerated rate of A-beta deposition starting at 2.5 months of age
• by 6 months of age deposition has become widespread and numerous in cortical, hippocampal and thalamic areas
• astrocytic and microglial activation around amyloid plaques

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:93770
Alzheimer Disease; AD 104300 J:93770




Genotype
MGI:5003501
cx2
Allelic
Composition
Psen1tm1Lpr/Psen1tm1Lpr
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Lpr mutation (0 available); any Psen1 mutation (28 available)
Tg(Thy1-APPSL)28Lpr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)
• amyloid beta plaques form but no intracellular aggregates are seen
• numerous plaques form between 2 and 6 months of age and the pathology increases with age
• unlike in the frontal cortex, no neuronal loss is detected in the thalamus
• the granule cell layer is less densely packed at 12 months of age compared to 2 months of age
• the granule cell border is often frayed
• ectopic cells that are often orientated towards extracellular amyloid deposits can be detected at 2 months of age
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus
• decrease in the number of dentate gyrus granule cells at 12 months of age
• decrease in the number of dentate gyrus granule cells at 12 months of age
• massive intra- and extra-cellular amyloid beta deposits are detected in the frontal cortex at as early as 1.5 months of age, before significant plaque formation is detected
• by 6 months of age intracellular accumulations are no longer a prominent pathological feature
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls
• frontal cortex volume is reduced compared to controls at 6 and 12 months of age
• thickened and irregularly shaped neurites are seen in the medulla at 14 months of age
• axonal spheroids are detected in pons and cortical areas at 6 months of age and in the spinal cord mostly along the anterior margin of the ventral horn and less frequently in the intermediolateral and dorsal horn
• at 10 and 14 months of age axonal spheroids are detected in pons, cortex, medulla, midbrain, hippocampus, corpus callosum and striatum
• larger axonal varicosities are seen in the medulla at 14 months of age
• large axonal dilatations are localized in white matter fiber tracts in close vicinity to the ventral horn in the spinal cord
• dilated axons often display thinned or focally absent myelin sheaths
• increased deposition of myelin ovoids in the white matter
• a 28% and 35% loss of neurons is seen in the frontal cortex at 6 and 12 months of age, respectively, compared to age-matched controls

homeostasis/metabolism
• significant decrease in plasma cholesterol between 2 and 6 months of age that is not seen in wild-type controls or either single transgenic mice
• basal cholesterol levels are increase compared to wild-type controls probably as a result of differences in strain background
• some plaques are detected at 2 months of age in the cervical spinal cord and plaques increase with age (J:128106)
• plaque formation is higher in the cervical spinal cord compared to the thoracic and lumbar regions (J:128106)
• plaques are almost exclusively found in the gray matter (J:128106)
• amyloid plaques are located frequently within the granular cell layer of the dentate gyrus (J:139736)
• significant plaque formation is detected in the frontal cortex by 2 months of age (J:146342)
• from 6 to 12 months of age plaques become more densely packed (J:146342)

behavior/neurological
• at 10 and 14 months of age
• impaired performance in a balance beam test at 10 and 14 months of age

growth/size/body
• at 10 and 14 months of age compared to mutant mice not carrying the transgene

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:128106




Genotype
MGI:5003459
cx3
Allelic
Composition
Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)
• non-corrected intracranial and brain volumes are reduced compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 10 weeks of age
• corrected brain volumes are strongly decreased with age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• significant increase in brain length with age compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• surface area of the internal capsule does not increase with age unlike in Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics
• decrease in thickness of the caudal corpus callosum with age
• decrease in fornix diameter in aged mice
• age-related decline in mean synaptic bouton densities within the stratum lucidum of area CA3
• age-related decline in mean synaptic bouton densities and in mean volume
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer, stratum lucidum of area CA3, and stratum radiatum of area CA1?2
• global brain atrophy in aged mice

homeostasis/metabolism
• significant decrease in plasma cholesterol between 3 and 13 months of age that is not seen in wild-type controls
• plasma cholesterol levels are reduced compared to wild-type controls at 13 months of age but not at 3 months of age
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 4.5 and 17 months of age (J:99507)
• abundant amyloid beta neuropil deposits in hippocampal and cortical areas in aged mice (J:128243)

growth/size/body
• brain weight to body weight ratio is increased compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics at 24 months of age
• in aged mice compared to Tg(Hmgcr-PSEN1*M146L)#Lpr single transgenics

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507




Genotype
MGI:5003504
tg4
Allelic
Composition
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSL)28Lpr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• enhanced lethality at young ages (less than 4 months of age)

behavior/neurological
• spend more time in the closed arms of an elevated plus maze at 15 months of age compared to age matched controls
• cross fewer segments and show a reduced latency to fall in a stationary beam test at 15 months of age
• significant decrease in latency to fall in a wire grid assay at 3 and 15, but not at 6, months of age
• significant decrease in latency to fall in a coat hanger assay at 15 months of age
• at 3, 6, and 15 months of age in an open field test
• activity decreases with age

nervous system
• increase in brain length but not weight

growth/size/body
• from 3 to 15 months of age

homeostasis/metabolism




Genotype
MGI:5003460
tg5
Allelic
Composition
Tg(Thy1-APPSL)28Lpr/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)
• levels of SDS-soluble amyloid beta protein are higher in females than in males at 3 months of age
• age-related decline in mean synaptic bouton densities
• age-related decline in mean synaptic bouton densities in area CA1?2
• clusters of swollen and abnormally distorted neuritic profiles are seen
• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer and stratum radiatum of area CA1?2
• elevated levels of lipid peroxidation products in brain homogenates in females at 3 months of age and in males and females at 12 months of age
• reduced levels of antioxidant enzymes at 3 and 12 months of age
• impaired mitochondrial function

cellular
• mitochondrial membrane potentials and ATP levels are reduced in dissociated brain cells at 3 months of age
• inhibition of complex IV and significantly reduced cytochrome c oxidase activity in cerebral isolated mitochondria
• state 3 and state 4 respiration are significantly reduced in freshly isolated cerebral mitochondria at 17 months of age

homeostasis/metabolism
• plaques are seen at 6 months of age (J:86694)
• detected in the hippocampus at 17 months of age (J:99507)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86694 , J:99507





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory