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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APPSw)40Btla
transgene insertion 40, Bruce Lamb
MGI:3510594
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693489
cx2
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693490
cx3
Brabq2C57BL/6J/Brabq2C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817995
cx4
Brabq3DBA/2J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817996
cx5
Brabq3C57BL/6J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817997
cx6
Brabq3C57BL/6J/Brabq3C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817998
cx7
Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817990
cx8
Brabq1C57BL/6J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817991
cx9
Brabq1C57BL/6J/Brabq1C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817992
cx10
Brabq2DBA/2J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817993
cx11
Brabq2C57BL/6J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817994
tg12
Tg(APPSw)40Btla/Tg(APPSw)40Btla B6.129-Tg(APPSw)40Btla MGI:3722393
tg13
Tg(APPSw)40Btla/Tg(APPSw)40Btla D2.129-Tg(APPSw)40Btla MGI:3722394
tg14
Tg(APPSw)40Btla/Tg(APPSw)40Btla involves: 129S1/Sv * 129X1/SvJ MGI:3693493
tg15
Tg(APPSw)40Btla/0 involves: 129S1/Sv * 129X1/SvJ MGI:3693439


Genotype
MGI:3693489
cx1
Allelic
Composition
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

homeostasis/metabolism
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months




Genotype
MGI:3693490
cx2
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (0 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

homeostasis/metabolism
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months




Genotype
MGI:3817995
cx3
Allelic
Composition
Brabq2C57BL/6J/Brabq2C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817996
cx4
Allelic
Composition
Brabq3DBA/2J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817997
cx5
Allelic
Composition
Brabq3C57BL/6J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817998
cx6
Allelic
Composition
Brabq3C57BL/6J/Brabq3C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817990
cx7
Allelic
Composition
Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817991
cx8
Allelic
Composition
Brabq1C57BL/6J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817992
cx9
Allelic
Composition
Brabq1C57BL/6J/Brabq1C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817993
cx10
Allelic
Composition
Brabq2DBA/2J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817994
cx11
Allelic
Composition
Brabq2C57BL/6J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3722393
tg12
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
B6.129-Tg(APPSw)40Btla
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

homeostasis/metabolism
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:86629




Genotype
MGI:3722394
tg13
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
D2.129-Tg(APPSw)40Btla
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no amyloid beta deposits are observed in 13.5 month-old mice




Genotype
MGI:3693493
tg14
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age

homeostasis/metabolism
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age




Genotype
MGI:3693439
tg15
Allelic
Composition
Tg(APPSw)40Btla/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

homeostasis/metabolism
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:42613





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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory