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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APPSw)40Btla
transgene insertion 40, Bruce Lamb
MGI:3510594
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693489
cx2
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3693490
cx3
Brabq2C57BL/6J/Brabq2C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817995
cx4
Brabq3DBA/2J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817996
cx5
Brabq3C57BL/6J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817997
cx6
Brabq3C57BL/6J/Brabq3C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817998
cx7
Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817990
cx8
Brabq1C57BL/6J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817991
cx9
Brabq1C57BL/6J/Brabq1C57BL/6J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817992
cx10
Brabq2DBA/2J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817993
cx11
Brabq2C57BL/6J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
involves: C57BL/6J * DBA/2J MGI:3817994
tg12
Tg(APPSw)40Btla/Tg(APPSw)40Btla B6.129-Tg(APPSw)40Btla MGI:3722393
tg13
Tg(APPSw)40Btla/Tg(APPSw)40Btla D2.129-Tg(APPSw)40Btla MGI:3722394
tg14
Tg(APPSw)40Btla/Tg(APPSw)40Btla involves: 129S1/Sv * 129X1/SvJ MGI:3693493
tg15
Tg(APPSw)40Btla/0 involves: 129S1/Sv * 129X1/SvJ MGI:3693439


Genotype
MGI:3693489
cx1
Allelic
Composition
Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

homeostasis/metabolism
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months




Genotype
MGI:3693490
cx2
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
Tg(PSEN1H163R)G9Btla mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

homeostasis/metabolism
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months




Genotype
MGI:3817995
cx3
Allelic
Composition
Brabq2C57BL/6J/Brabq2C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq2C57BL/6J mutation (0 available); any Brabq2 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817996
cx4
Allelic
Composition
Brabq3DBA/2J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq3DBA/2J mutation (0 available); any Brabq3 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817997
cx5
Allelic
Composition
Brabq3C57BL/6J/Brabq3DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq3C57BL/6J mutation (0 available); any Brabq3 mutation (0 available)
Brabq3DBA/2J mutation (0 available); any Brabq3 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817998
cx6
Allelic
Composition
Brabq3C57BL/6J/Brabq3C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq3C57BL/6J mutation (0 available); any Brabq3 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817990
cx7
Allelic
Composition
Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq1DBA/2J mutation (0 available); any Brabq1 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817991
cx8
Allelic
Composition
Brabq1C57BL/6J/Brabq1DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq1C57BL/6J mutation (0 available); any Brabq1 mutation (0 available)
Brabq1DBA/2J mutation (0 available); any Brabq1 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817992
cx9
Allelic
Composition
Brabq1C57BL/6J/Brabq1C57BL/6J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq1C57BL/6J mutation (0 available); any Brabq1 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3817993
cx10
Allelic
Composition
Brabq2DBA/2J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq2DBA/2J mutation (0 available); any Brabq2 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

homeostasis/metabolism
• decreased levels of brain amyloid beta




Genotype
MGI:3817994
cx11
Allelic
Composition
Brabq2C57BL/6J/Brabq2DBA/2J
Tg(APPSw)40Btla/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brabq2C57BL/6J mutation (0 available); any Brabq2 mutation (0 available)
Brabq2DBA/2J mutation (0 available); any Brabq2 mutation (0 available)
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased levels of brain amyloid beta

homeostasis/metabolism
• increased levels of brain amyloid beta




Genotype
MGI:3722393
tg12
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
B6.129-Tg(APPSw)40Btla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

homeostasis/metabolism
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:86629




Genotype
MGI:3722394
tg13
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
D2.129-Tg(APPSw)40Btla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no amyloid beta deposits are observed in 13.5 month-old mice




Genotype
MGI:3693493
tg14
Allelic
Composition
Tg(APPSw)40Btla/Tg(APPSw)40Btla
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age

homeostasis/metabolism
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age




Genotype
MGI:3693439
tg15
Allelic
Composition
Tg(APPSw)40Btla/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSw)40Btla mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

homeostasis/metabolism
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:42613





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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory