Mouse Genome Informatics
cx1
    Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

homeostasis/metabolism
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months


Mouse Genome Informatics
cx2
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

homeostasis/metabolism
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months


Mouse Genome Informatics
cx3
    Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females