Mouse Genome Informatics
cx1
    Tg(APPSw)40Btla/0
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months

other phenotype
• double hemizygous mice show a 10- to 12-fold higher increase in Abeta1-42 amyloid peptide accumulation compared to Tg(PSEN1H163R)G9Btla mice
• mice develop scattered, fibrillar amyloid beta deposits in frontal cortex at 18-20 months


Mouse Genome Informatics
cx2
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
Tg(PSEN1H163R)G9Btla/0

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months

other phenotype
• mice develop extensive amyloid beta fibrillar deposits in brain by 7 months


Mouse Genome Informatics
cx3
    Brabq1DBA/2J/Brabq1DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

other phenotype
• decreased levels of brain amyloid beta


Mouse Genome Informatics
cx4
    Brabq1C57BL/6J/Brabq1DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

other phenotype
• decreased levels of brain amyloid beta


Mouse Genome Informatics
cx5
    Brabq1C57BL/6J/Brabq1C57BL/6J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased levels of brain amyloid beta

other phenotype
• increased levels of brain amyloid beta


Mouse Genome Informatics
cx6
    Brabq2DBA/2J/Brabq2DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

other phenotype
• decreased levels of brain amyloid beta


Mouse Genome Informatics
cx7
    Brabq2C57BL/6J/Brabq2DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased levels of brain amyloid beta

other phenotype
• increased levels of brain amyloid beta


Mouse Genome Informatics
cx8
    Brabq2C57BL/6J/Brabq2C57BL/6J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased levels of brain amyloid beta

other phenotype
• increased levels of brain amyloid beta


Mouse Genome Informatics
cx9
    Brabq3DBA/2J/Brabq3DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• decreased levels of brain amyloid beta

other phenotype
• decreased levels of brain amyloid beta


Mouse Genome Informatics
cx10
    Brabq3C57BL/6J/Brabq3DBA/2J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased levels of brain amyloid beta

other phenotype
• increased levels of brain amyloid beta


Mouse Genome Informatics
cx11
    Brabq3C57BL/6J/Brabq3C57BL/6J
Tg(APPSw)40Btla/0

involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• increased levels of brain amyloid beta

other phenotype
• increased levels of brain amyloid beta


Mouse Genome Informatics
tg12
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
B6.129-Tg(APPSw)40Btla
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

other phenotype
• all animals show amyloid beta (Abeta) deposits in the parietal cortex at 13.5 months of age, but no animals have deposits at 5 months

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:86629


Mouse Genome Informatics
tg13
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
D2.129-Tg(APPSw)40Btla
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• no amyloid beta deposits are observed in 13.5 month-old mice (J:86629)


Mouse Genome Informatics
tg14
    Tg(APPSw)40Btla/Tg(APPSw)40Btla
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age

other phenotype
• homozygous mice have 15- to 20-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes
• extensive fibrillar amyloid beta deposits are detected in the hippocampus and frontal, cingulate and parietal cortex at 14-15 months of age


Mouse Genome Informatics
tg15
    Tg(APPSw)40Btla/0
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

other phenotype
• mice have higher levels of total A-beta protein and the cleaved A-beta 1-42(43) peptide than Tg(APP)8.9Btla mice, but levels are lower than those in Tg(APPSwLon)96Btla mice (J:42613)
• mice have 7- to 8-fold higher levels of Abeta1-42 peptide in their brains compared to Tg(PSEN1H163R)G9Btla hemizygotes (J:58050)
• diffuse amyloid beta deposits are detected in the hippocampus and frontal cortex at 24-26 months of age (J:58050)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:42613