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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-Bgeo/ALPP)1Lbe
transgene insertion 1, Corrinne Lobe
MGI:3505556
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4836240
cn2
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
involves: 129S1/Sv * 129X1/SvJ MGI:5749827
cn3
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Ins2-cre/ERT)1Dam/0
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-DTA)1Gfi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3770687
cn4
Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm4(DTA)Whk/Pou4f2+
Tg(CAG-Bgeo/ALPP)1Lbe/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5285913
cx5
Npr2tm2.1(cre/ERT2)Fgr/Npr2cn
Tg(CAG-Bgeo/ALPP)1Lbe/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J MGI:5568088
tg6
Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3803740


Genotype
MGI:4836240
cn1
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Cela1-cre/ERT)1Dam/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (81 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
Tg(Cela1-cre/ERT)1Dam mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• 4 weeks after tamoxifen injections to induce Cre expression, pancreata exhibit no ductal metaplasia




Genotype
MGI:5749827
cn2
Allelic
Composition
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0
Tg(Hoxb3-cre)1Pkht/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
Tg(CAG-en/Hoxb5,-EGFP)#Vchl mutation (0 available)
Tg(Hoxb3-cre)1Pkht mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

cellular
• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine




Genotype
MGI:3770687
cn3
Allelic
Composition
Tg(CAG-Bgeo/ALPP)1Lbe/0
Tg(Ins2-cre/ERT)1Dam/0
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-DTA)1Gfi/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
Tg(Ins2-cre/ERT)1Dam mutation (2 available)
Tg(Ins2-rtTA)2Efr mutation (2 available)
Tg(tetO-DTA)1Gfi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• tamoxifen injections during last 10 days of doxycycline treatment labels surviving beta cells with human placental alkaline phosphatase; labeling results indicate that majority or all regenerated beta cells are derived from surviving beta cells, rather than from non-beta cells or stem cells

homeostasis/metabolism
• treatment of newborn mice with doxycycline for 45 days results in diabetes development




Genotype
MGI:5285913
cn4
Allelic
Composition
Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm4(DTA)Whk/Pou4f2+
Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1.1(cre)Saha mutation (0 available); any Opn4 mutation (33 available)
Pou4f2tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls
• innervation of the intergeniculate leaflet (IGL) is markedly reduced
• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2tm2.1Nat/+ Opn4tm1.1(cre)Saha/+ animals

vision/eye
• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2tm2.1Nat/+ Opn4tm1.1(cre)Saha/+ animals




Genotype
MGI:5568088
cx5
Allelic
Composition
Npr2tm2.1(cre/ERT2)Fgr/Npr2cn
Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2cn mutation (2 available); any Npr2 mutation (61 available)
Npr2tm2.1(cre/ERT2)Fgr mutation (0 available); any Npr2 mutation (61 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• at E15.5 formation of collaterals by cranial sensory axons is not affected by Npr2 deficiency
• peripheral processes of the ophthalmic branch of the trigeminal nerve are not significantly affected by Npr2 deficiency
• at E12.5 axons from cranial sensory ganglia do not bifurcate at the entry zone to the brainstem
• mice lack axon bifurcation of DRG neurons; axons only exhibit only turns with Npr2 deficiency




Genotype
MGI:3803740
tg6
Allelic
Composition
Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are not viable; line is maintained and used in hemizygous state





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory