All Phenotypes Raf1<tm2Bacc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Raf1^tm2Bacc
targeted mutation 2, Manuela Baccarini
MGI:3497907

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd	MGI:5508348
cn2	Kras^tm1Bbd/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508337
cn3	Braf^tm1Sva/Braf^tm1Sva Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508357
cn4	Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508355
cn5	Braf^tm1Sva/Braf^tm1Sva Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5508350
cn6	Braf^tm1Sva/Braf^tm1Sva Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3713578
cn7	Braf^tm1Sva/Braf^tm1Sva Raf1^tm2Bacc/Raf1⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3713555
cn8	Braf^tm1Wds/Braf^tm1.1Wds Raf1^tm1Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3713654
cn9	Braf^tm1Sva/Braf^tm1.1Sva Raf1^tm1Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3713581
cn10	Kras^tm4Tyj/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5510702
cn11	Meox2^tm1(cre)Sor/Meox2⁺ Raf1^tm2Bacc/Raf1^tm2.1Bacc	involves: 129P2/OlaHsd * 129S4/SvJaeSor	MGI:3622526
cn12	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1^tm2Bacc	involves: 129P2/OlaHsd * C57BL/6	MGI:3713541
cn13	Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3511182
cn14	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1^tm2Bacc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:5659950
cn15	Braf^tm1Sva/Braf⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3713653
cn16	Braf^tm1Wds/Braf⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3713540
cn17	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3713536
cn18	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J	MGI:3510548
cn19	Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J	MGI:3510547

Allelic Composition	Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:172200 )

• 30 day old mice fed a tamoxifen diet for 3 months show normal weight and activity and no obvious anatomical defects

Allelic Composition	Kras^tm1Bbd/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172200 )

• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), mice show 50% survival at 63 weeks compared to 38 weeks in single Kras heterozygous controls, indicating an 83% increase in survival

neoplasm

decreased classified tumor incidence ( J:172200 )

• tumor burden is reduced compared to single Kras heterozygotes; tumors that are found express Raf1

Allelic Composition	Braf^tm1Sva/Braf^tm1Sva Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Sva mutation (1 available); any Braf mutation (58 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell proliferation ( J:172200 )

• primary mouse embryonic fibroblasts exposed to 4OHT for 5 days to activate cre/ERT2 recombinase exhibit decreased proliferation that is similar to that in single Kras mutants without further additive effects

Allelic Composition	Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell proliferation ( J:172200 )

• primary mouse embryonic fibroblasts exposed to 4OHT for 5 days to activate cre/ERT2 recombinase exhibit decreased proliferation compared to single Kras heterozygotes

Allelic Composition	Braf^tm1Sva/Braf^tm1Sva Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Sva mutation (1 available); any Braf mutation (58 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:172200 )

• 30 day old mice fed a tamoxifen diet for 3 months are healthy and show normal weight and activity and no obvious anatomical defects

Allelic Composition	Braf^tm1Sva/Braf^tm1Sva Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Sva mutation (1 available); any Braf mutation (58 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:121660 )

• cultured DRG neurons transfected with Cre-EGFP have very short axons, compared to long and dense axon networks formed by control neurons

cellular

abnormal axon extension ( J:121660 )

• cultured DRG neurons transfected with Cre-EGFP have very short axons, compared to long and dense axon networks formed by control neurons

Allelic Composition	Braf^tm1Sva/Braf^tm1Sva Raf1^tm2Bacc/Raf1⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:121660 )

• most die before weaning

growth/size/body

postnatal growth retardation ( J:121660 )

• mice are smaller in the postnatal period than Braf conditional knockouts

nervous system

abnormal innervation ( J:121660 )

• deficiency of terminal axonal projections of parvalbumin-positive neurons toward the lateral motor pools of the spinal cord is seen compared to controls

abnormal sensory neuron innervation pattern ( J:121660 )

• proprioceptive axons enter spinal cord normally, but few progress beyond intermediate zone

abnormal dorsal root ganglion morphology ( J:121660 )

• at P12, number of Ret+ neurons in DRG is reduced; numbers of CGRG+ neurons are increased

Allelic Composition	Braf^tm1Wds/Braf^tm1.1Wds Raf1^tm1Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1.1Wds mutation (0 available); any Braf mutation (58 available)
Braf^tm1Wds mutation (0 available); any Braf mutation (58 available)
Raf1^tm1Bacc mutation (0 available); any Raf1 mutation (114 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121660 )

• no double conditional embryos are found live at E14-15, but can be isolated at E13

nervous system

abnormal axon extension ( J:121660 )

• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth

abnormal innervation ( J:121660 )

• sensory nerve trunks form normally, but distal arborization is reduced compared to controls

abnormal dorsal root ganglion morphology ( J:121660 )

• at E13, Ret levels in DRGs are reduced

cellular

abnormal axon extension ( J:121660 )

• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth

Allelic Composition	Braf^tm1Sva/Braf^tm1.1Sva Raf1^tm1Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1.1Sva mutation (0 available); any Braf mutation (58 available)
Braf^tm1Sva mutation (1 available); any Braf mutation (58 available)
Raf1^tm1Bacc mutation (0 available); any Raf1 mutation (114 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121660 )

• no double conditional embryos are found live at E14-15, but can be isolated at E13

nervous system

abnormal axon extension ( J:121660 )

• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth

abnormal innervation ( J:121660 )

• sensory nerve trunks form normally, but distal arborization is reduced compared to controls

abnormal dorsal root ganglion morphology ( J:121660 )

• at E13, Ret levels in DRGs are reduced

cellular

abnormal axon extension ( J:121660 )

• DRG neurons cultured with NGF for 5 days show impaired axon outgrowth

Allelic Composition	Kras^tm4Tyj/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• as in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• as in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Raf1^tm2Bacc/Raf1^tm2.1Bacc
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Raf1^tm2.1Bacc mutation (0 available); any Raf1 mutation (114 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:105998 )

• live embryos are present at E10.5 but none survive to birth

Allelic Composition	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1^tm2Bacc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Wds mutation (0 available); any Braf mutation (58 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:121660 )

• cultured DRG neurons transfected with Cre-EGFP have very short axons, compared to long and dense axon networks formed by control neurons

cellular

abnormal axon extension ( J:121660 )

• cultured DRG neurons transfected with Cre-EGFP have very short axons, compared to long and dense axon networks formed by control neurons

Allelic Composition	Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:93687 )

• macrophages more sensitive to Salmonella induced apoptosis

• kinetics of apoptosis faster

• specific to Salmonella infection

Allelic Composition	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1^tm2Bacc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Wds mutation (0 available); any Braf mutation (58 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:144862 )

• mice die in late gestation

cardiovascular system

persistent truncus arteriosus ( J:144862 )

• in 4 of 6 mice at E17.5

abnormal conotruncus morphology ( J:144862 )

• mild conotruncal defects at E16.5

double outlet right ventricle ( J:144862 )

• at E16.5

ventricular septal defect ( J:144862 )

• in 4 of 6 mice at E17.5 with 1 mouse also exhibiting double outlet right ventricle

endocrine/exocrine glands

small thymus ( J:144862 )

• in 5 of 8 mice at E16.5 and E17.5

abnormal thyroid gland morphology ( J:144862 )

• hypoplastic or malpositioned in 2 of 3 mice at E16.5

small thyroid gland ( J:144862 )

• hypoplastic or malpositioned in 2 of 3 mice at E16.5

craniofacial

mandible hypoplasia ( J:144862 )

short maxilla ( J:144862 )

growth/size/body

growth/size/body region phenotype ( J:144862 )

N	• mice exhibit normal embryonic crown-rump length

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:144862 )

N	• mice exhibit normal external ear

skeleton

mandible hypoplasia ( J:144862 )

short maxilla ( J:144862 )

immune system

small thymus ( J:144862 )

• in 5 of 8 mice at E16.5 and E17.5

hematopoietic system

small thymus ( J:144862 )

• in 5 of 8 mice at E16.5 and E17.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiofaciocutaneous syndrome		DOID:0060233	OMIM:PS115150	J:144862

Allelic Composition	Braf^tm1Sva/Braf⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121660 )

• mice show no phenotypic abnormalities at any stage

Allelic Composition	Braf^tm1Wds/Braf⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:121660 )

• mice show no phenotypic abnormalities at any stage

Allelic Composition	Braf^tm1Wds/Braf^tm1Wds Raf1^tm2Bacc/Raf1⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:121660 )

• most die before weaning

growth/size/body

postnatal growth retardation ( J:121660 )

• mice are smaller in the postnatal period than Braf conditional knockouts

nervous system

abnormal innervation ( J:121660 )

• deficiency of terminal axonal projections of parvalbumin-positive neurons toward the lateral motor pools of the spinal cord is seen compared to controls

abnormal sensory neuron innervation pattern ( J:121660 )

• proprioceptive axons enter spinal cord normally, but few progress beyond intermediate zone

abnormal dorsal root ganglion morphology ( J:121660 )

• at P12, number of Ret+ neurons in DRG is reduced; numbers of CGRG+ neurons are increased

Allelic Composition	Map3k5^tm1Hijo/Map3k5^tm1Hijo Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k5^tm1Hijo mutation (4 available); any Map3k5 mutation (61 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:93418 )

N	• heart size, morphology and function are not significantly different from wild-type unlike Raf1^tm2Bacc, Tg(Myhca-cre)2182Mds mutants

Allelic Composition	Raf1^tm2Bacc/Raf1^tm2Bacc Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thin myocardium ( J:93418 )

• posterior wall thickness is significantly decreased

enlarged heart ( J:93418 )

• the heart is enlarged; however, heart weight is not increased

dilated heart left ventricle ( J:93418 )

cardiac fibrosis ( J:93418 )

decreased cardiac muscle contractility ( J:93418 )

• fractional shortening indicate that cardiac contractility is significantly decreased

decreased ventricle muscle contractility ( J:93418 )

• reduced maximal and minimal first derivatives of left ventricular pressure indicate that cardiac contractility and relaxation are significantly decreased

increased cardiomyocyte apoptosis ( J:93418 )

• increased apoptosis in the heart is seen from 3-5 weeks of age but not at 2 weeks or after 6 weeks of age

muscle

thin myocardium ( J:93418 )

• posterior wall thickness is significantly decreased

decreased cardiac muscle contractility ( J:93418 )

• fractional shortening indicate that cardiac contractility is significantly decreased

decreased ventricle muscle contractility ( J:93418 )

• reduced maximal and minimal first derivatives of left ventricular pressure indicate that cardiac contractility and relaxation are significantly decreased

increased cardiomyocyte apoptosis ( J:93418 )

• increased apoptosis in the heart is seen from 3-5 weeks of age but not at 2 weeks or after 6 weeks of age

cellular

increased cardiomyocyte apoptosis ( J:93418 )

• increased apoptosis in the heart is seen from 3-5 weeks of age but not at 2 weeks or after 6 weeks of age

growth/size/body

enlarged heart ( J:93418 )

• the heart is enlarged; however, heart weight is not increased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23