Phenotypes associated with this allele

• Allele Symbol: Pkp2^tm1Wbm
• Allele Name: targeted mutation 1, Walter Birchmeier
• Allele ID: MGI:3487374
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkp2^tm1Wbm/Pkp2^tm1Wbm	involves: C57BL/6	MGI:3510249

Genotype
MGI:3510249

hm1

• Allelic Composition: Pkp2^tm1Wbm/Pkp2^tm1Wbm
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

E10.75 Pkp2^tm1Wbm/Pkp2^tm1Wbm embryos accumulate blood in pericardial and peritoneal cavities and lack red blood cells in the yolk sac vasculature

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93314 )

• homozygous embryos begin to die around E11.5

cardiovascular system

abnormal heart morphology ( J:93314 )

abnormal myocardium layer morphology ( J:93314 )

• the adhering junctions between cardiomyocytes are abnormal and disarrayed cytoskeleton architecture is seen

trabecula carnea hypoplasia ( J:93314 )

• at E10.75 trabeculation is reduced

abnormal heart atrium morphology ( J:93314 )

• thinner atrial walls are seen, however overt ruptures of the heart walls are not seen

pericardial edema ( J:93314 )

abnormal blood circulation ( J:93314 )

hemopericardium ( J:93314 )

hemoperitoneum ( J:93314 )

poor circulation ( J:93314 )

• at E10.75 blood accumulates in the pericardium and peritoneum while little blood is seen in the vessels of head, dorsal trunk, and yolk sac

homeostasis/metabolism

hemopericardium ( J:93314 )

edema ( J:93314 )

• at E11.5-E12 peritoneal and pericardial edema are seen

pericardial edema ( J:93314 )

muscle

abnormal myocardium layer morphology ( J:93314 )

• the adhering junctions between cardiomyocytes are abnormal and disarrayed cytoskeleton architecture is seen

trabecula carnea hypoplasia ( J:93314 )

• at E10.75 trabeculation is reduced

cellular

abnormal cell cytoskeleton morphology ( J:93314 )

• the adhering junctions between cardiomyocytes are abnormal and disarrayed cytoskeleton architecture is seen