Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
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normal phenotype
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• homozygotes are normal and fertile with no rib fusions detected
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neoplasm
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• 1 in 12 mice develop an rhabdomyosarcoma by day 202
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muscle
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• 1 in 12 mice develop an rhabdomyosarcoma by day 202
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neoplasm
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• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91
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muscle
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• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Mrc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
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mortality/aging
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• pups are immobile and die shortly after birth
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muscle
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• myogenesis appears normal at E12.5
• increasing apoptosis until all differentiating myofibers are either dead or dying at E18.5
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• newborns lack differentiated myofibers
• basophilic clumps of cellular debris suggest skeletal muscle forms and then degenerates
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
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mortality/aging
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• mice die by 6 months of age
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neoplasm
N |
• unlike in other Gt(ROSA)26Sortm3(SS18)Mrc homozygously activated mice, no tumors form
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muscle
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• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SS18)Mrc mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
|
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mortality/aging
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• mice die by 6 months of age
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neoplasm
N |
• unlike in other Gt(ROSA)26Sortm2(SS18)Mrc homozygously activated mice, no tumors form
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muscle
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• intrafiber vacuolation is present in some muscle fibers
• apoptosis of differentiated skeletal muscle fibers is increased
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• central nuclei are present in some muscle fibers
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• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm4Rdp mutation
(0 available);
any
Cdkn2a mutation
(62 available)
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
Pax3tm1Mrc mutation
(1 available);
any
Pax3 mutation
(50 available)
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neoplasm
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• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89
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muscle
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• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
Pax3tm1Mrc mutation
(1 available);
any
Pax3 mutation
(50 available)
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neoplasm
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• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383
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muscle
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• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Mrc mutation
(0 available);
any
Foxo1 mutation
(31 available)
Myf6tm1(cre)Mrc mutation
(0 available);
any
Myf6 mutation
(19 available)
Pax3tm1Mrc mutation
(1 available);
any
Pax3 mutation
(50 available)
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neoplasm
N |
• mice do not exhibit accelerated tumorigenesis
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