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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(GFAP-cre)#Gtm
transgene insertion #, David H Gutmann
MGI:3057344
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Itgavtm2Hyn/Itgavtm2.1Hyn
Tg(GFAP-cre)#Gtm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5306155
cn2
Nf1tm1Par/Nf1tm1Fcr
Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4838320
cn3
Nf1tm1Fcr/Nf1+
Tsc1tm1Djk/Tsc1tm1Djk
Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA MGI:5292550
cn4
Nf1tm1Fcr/Nf1+
Tg(GFAP-cre)#Gtm/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA MGI:5292552
cn5
Tsc1tm1Djk/Tsc1tm1Djk
Tg(GFAP-cre)#Gtm/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5292549
cn6
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5543816
cn7
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
involves: C57BL/6 * CBA MGI:5292547


Genotype
MGI:5306155
cn1
Allelic
Composition
Itgavtm2Hyn/Itgavtm2.1Hyn
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgavtm2.1Hyn mutation (0 available); any Itgav mutation (23 available)
Itgavtm2Hyn mutation (0 available); any Itgav mutation (23 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E18 and P5, mice exhibit microhemorrhage in the cerebellum, mid-brain, and cerebral cortex unlike in control mice
• at E18 and P5, mice exhibit microhemorrhage in the cerebellum unlike in control mice
• at E18 and P5, mice exhibit microhemorrhage in the cerebral cortex unlike in control mice
• between P7 and P14, mice exhibit progressive reduction in cerebral microhemorrhage
• however, adult mice exhibit no hemorrhage or edema in the brain

nervous system
• at E18 and P5, mice exhibit microhemorrhage in the cerebellum, mid-brain, and cerebral cortex unlike in control mice
• at E18 and P5, mice exhibit microhemorrhage in the cerebellum unlike in control mice
• at E18 and P5, mice exhibit microhemorrhage in the cerebral cortex unlike in control mice
• between P7 and P14, mice exhibit progressive reduction in cerebral microhemorrhage
• however, adult mice exhibit no hemorrhage or edema in the brain




Genotype
MGI:4838320
cn2
Allelic
Composition
Nf1tm1Par/Nf1tm1Fcr
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (75 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (75 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas

immune system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas

nervous system
• at 9 months of age, mutants have significantly more microglia than controls; microglia are in the optic gliomas
• irregularly shaped and thickened astrocytes are seen in the pre-chiasmatic optic nerves
• retinal ganglion cell loss in the middle and peripheral region
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration
• mice exhibit abnormal optic nerve axon organization
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma)
• mice develop optic gliomas in the optic chiasm/nerves
• optic gliomas appear as gross thickenings and enlargements of the pre-chiasmic nerve at 9 months of age
• axonal and myelin degeneration are seen in the optic nerve
• increase in neoplastic astrocyte proliferation in the optic glioma
• disruption of the myelin is seen in the optic nerve, including degeneration and hypermyelination
• hypermyelination is seen in the optic nerve

tumorigenesis
• mice develop optic gliomas in the optic chiasm/nerves
• optic gliomas appear as gross thickenings and enlargements of the pre-chiasmic nerve at 9 months of age

vision/eye
• retinal ganglion cell loss in the middle and peripheral region
• optic gliomas form in the pre-chiasmatic optic nerve/optic chiasm, with increased vascularization to the area, abnormally shaped and thickened astrocytes, increase in microglia, and axonal and myelin degeneration
• mice exhibit abnormal optic nerve axon organization
• the optic chiasm/nerves at 9 months of age appear as gross fusiform enlargements that result in optic gliomas
• increase in vascularization in the pre-chiasmatic optic nerve and optic chiasm (and in the optic glioma)

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:165209




Genotype
MGI:5292550
cn3
Allelic
Composition
Nf1tm1Fcr/Nf1+
Tsc1tm1Djk/Tsc1tm1Djk
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (75 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
Tsc1tm1Djk mutation (1 available); any Tsc1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die before 3 months of age

tumorigenesis
N
• mice do not develop gliomas




Genotype
MGI:5292552
cn4
Allelic
Composition
Nf1tm1Fcr/Nf1+
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (75 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cell proliferation in the optic nerve is increased compared to in wild-type mice
• kinking of the prechiasmatic optic nerves
• optic gliomas

tumorigenesis
• optic gliomas

vision/eye
• kinking of the prechiasmatic optic nerves

cellular
• cell proliferation in the optic nerve is increased compared to in wild-type mice




Genotype
MGI:5292549
cn5
Allelic
Composition
Tsc1tm1Djk/Tsc1tm1Djk
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-cre)#Gtm mutation (0 available)
Tsc1tm1Djk mutation (1 available); any Tsc1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by 6 to 10 weeks of age

nervous system
• by 6 to 10 weeks of age

behavior/neurological
• by 6 to 10 weeks of age




Genotype
MGI:5543816
cn6
Allelic
Composition
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (317 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal GFAP+ and S100B+ astrocytes cell numbers




Genotype
MGI:5292547
cn7
Allelic
Composition
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA,CMV*1-Rheb,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (317 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal brain weight
• mice do not develop seizures
• astrocytes exhibit increased mTor signaling-dependent proliferation compared to in control cells

growth/size/body
N
• mice exhibit normal body weight





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory