Phenotypes associated with this allele

• Allele Symbol: Hsf4^tm1Anak
• Allele Name: targeted mutation 1, Akira Nakai
• Allele ID: MGI:3057199
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf4^tm1Anak/Hsf4^tm1Anak	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)	MGI:3057289
cx2	Hsf1^tm1Anak/Hsf1^tm1Anak Hsf4^tm1Anak/Hsf4^tm1Anak	involves: C57BL/6 * CBA * ICR	MGI:3057290

Genotype
MGI:3057289

hm1

• Allelic Composition: Hsf4^tm1Anak/Hsf4^tm1Anak
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:93301 )

• lens weight is reduced

abnormal lens capsule morphology ( J:93301 )

• the posterior lens capsule is thin

ruptured lens capsule ( J:93301 )

• ruptures in about 50% of mutant mice

abnormal lens epithelium morphology ( J:93301 )

• lens epithelial cells are columnar rather than cuboidal as in wild-type and display increased proliferation and premature differentiation into fiber cells in mutants

hydropic eye lens fibers ( J:93301 )

• at P2 lens fibers are swollen and contain inclusion-like structures, however at E15.5 lens fiber morphology is normal

cataract ( J:93301 )

Genotype
MGI:3057290

cx2

• Allelic Composition: Hsf1^tm1Anak/Hsf1^tm1Anak; Hsf4^tm1Anak/Hsf4^tm1Anak
• Genetic Background: involves: C57BL/6 * CBA * ICR

vision/eye

ruptured lens capsule ( J:93301 )

• the lens capsule is always ruptured; however, lens epithelial cell proliferation and morphology are fairly normal unlike in Hsf4^tm1Anak homozygotes

cataract ( J:93301 )

• more severe cataracts are seen compared to Hsf4^tm1Anak homozygotes