Mouse Genome Informatics
cx1
    Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0

NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6


Mouse Genome Informatics
cx2
    Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0

NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:91865


Mouse Genome Informatics
tg3
    Tg(Igh-6/Igh-V281)3Jwt/0
NOD.B6-Tg(Igh-6/Igh-V281)3Jwt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
• transgenic mice are protected from developing diabetes; 16% develop diabetes by 40 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:91865