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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Igh-6/Igh-V281)3Jwt
transgene insertion 3, James W Thomas
MGI:3056939
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt MGI:3623592
cx2
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt MGI:3623593
tg3
Tg(Igh-6/Igh-V281)3Jwt/0 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt MGI:3623591


Genotype
MGI:3623592
cx1
Allelic
Composition
Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (19 available); any Ighm mutation (29 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6




Genotype
MGI:3623593
cx2
Allelic
Composition
Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background
NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (19 available); any Ighm mutation (29 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:91865




Genotype
MGI:3623591
tg3
Allelic
Composition
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background
NOD.B6-Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
• transgenic mice are protected from developing diabetes; 16% develop diabetes by 40 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:91865





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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory