Phenotypes associated with this allele
immune system
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• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2mtm1Jae homozygote controls
• in the periphery, CD8+ T cells make up 2% of the lymph node population compared to less than 0.1% for B2mtm1Jae homozygote controls
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• lymph node cellularity is 25% that of controls, with a normal ratio between CD4+ and CD8+ T cells
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hematopoietic system
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• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2mtm1Jae homozygote controls
• in the periphery, CD8+ T cells make up 2% of the lymph node population compared to less than 0.1% for B2mtm1Jae homozygote controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LckNotch1)9Erob mutation
(1 available)
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immune system
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• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
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• thymocyte development is skewed towards development into the CD8 T cell lineage
• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice
• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC
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• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control
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• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls
• production of these single-positive CD8 thymocytes is increased 3-fold
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neoplasm
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• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology
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hematopoietic system
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• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
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• thymocyte development is skewed towards development into the CD8 T cell lineage
• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice
• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC
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• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control
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• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls
• production of these single-positive CD8 thymocytes is increased 3-fold
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endocrine/exocrine glands
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• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
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• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology
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Analysis Tools