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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Crebbptm1.2Ltz
targeted mutation 1.2, Beat Lutz
MGI:3056564
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0
involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J MGI:4941348


Genotype
MGI:4941348
cn1
Allelic
Composition
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1.2Ltz mutation (0 available); any Crebbp mutation (99 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal anxiety levels, fear conditioning, and spatial navigation
• after 3 consecutive days in the same arena, mice exhibit slightly less locomotor habituation compared with wild-type mice
• mice exhibit impaired long term recognition memory compared with wild-type mice

nervous system
N
• neuronal viability is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rubinstein-Taybi syndrome DOID:1933 OMIM:180849
OMIM:610543
OMIM:613684
J:168984





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory