Mouse Genome Informatics
hm1
    Hsf4ldis1/Hsf4ldis1
either: RIIIS/J or (involves: DBA/2J * RIIIS/J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• epithelial cells that normally terminate at the lens equator often extend all the way around the lens
• the lens capsule is disrupted allowing lens fibers to migrate behind the posterior lens capsule and nuclei of lens fibers are found throughout the lens unlike in DBA/2J wild-type mice
• cataracts with cortical and nuclear manifestations are seen
• at 9 weeks of age the intraocular lenses are dislocated temporally
• lens weight is reduced compared to DBA/2J wild-type mice
• eye size and weight are significantly smaller than DBA/2J wild-type mice


Mouse Genome Informatics
hm2
    Hsf4ldis1/Hsf4ldis1
involves: C57BL/6 * CAST/EiJ * RIIIS/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• persistence of nuclei in lens fiber cells as early as P0.5
• by P10-12, lenses develop severely vauolated cataracts often accompanied by rupture of the lens capsule and release of the lenticular material in the vitreous cavity, such that cataracts are visible upon eyelid opening between P12-14
• vacuoles are seen in the cortex and nucleus of the lens

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 5, Multiple Types; CTRCT5 116800 J:179658