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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dll4tm1Grid
targeted mutation 1, Tom Gridley
MGI:3056460
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Dll4tm1Grid/Dll4+ either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J) MGI:3056463


Genotype
MGI:3056463
ht1
Allelic
Composition
Dll4tm1Grid/Dll4+
Genetic
Background
either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm1Grid mutation (0 available); any Dll4 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only a single heterozygote was produced and no heterozygous pups were produced from mating this individual to wild-type Black Swiss females

cardiovascular system
• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein
• the capillary system is less extensive and more primitive compared to wild-type
• no vascular remodeling is seen at E9.5
• the distal outflow tract is connected to the anterior cardinal vein by an anastamoses
• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein
• the distal outflow tract is connected to the anterior cardinal vein by an anastamoses
• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein
• some vessels are reduced in diameter or atretic
• pericardial effusion is seen at E9.5 and E10.5

embryo
• embryonic growth retardation is seen at E9.5 and E10.5
• a mottled avascular yolk sac is seen at E9.5 and E10.5
• the yolk sac primary plexus is not remodeled

growth/size/body
• embryonic growth retardation is seen at E9.5 and E10.5

homeostasis/metabolism
• pericardial effusion is seen at E9.5 and E10.5

cellular
• no vascular remodeling is seen at E9.5





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory