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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctnnb1tm1.1Yy
targeted mutation 1.1, Yingzi Yang
MGI:3056114
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3687747
cn2
 		Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3687748


Genotype
MGI:3687747
cn1
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ptch1tm1.1Yy mutation (0 available); any Ptch1 mutation (115 available)
Ptch1tm1Yy mutation (0 available); any Ptch1 mutation (115 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
arrested osteoblast differentiation ( J:112462 )
• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

skeleton
arrested osteoblast differentiation ( J:112462 )
• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs
abnormal elbow joint morphology ( J:112462 )
• the elbow joint interzone fails to form
abnormal long bone hypertrophic chondrocyte zone ( J:112462 )
• chondrocyte hypertrophy is inhibited
fused synovial joints ( J:112462 )
• show extensive synovial joint fusions which are much more severe than in each of the single mutants
abnormal perichondrium morphology ( J:112462 )
• perichondrium is thinner
decreased bone mineralization ( J:112462 )
• mineralization in the long bones is more severely reduced than in single conditional Ctnnb1 mutants
delayed endochondral bone ossification ( J:112462 )
• ossification is more severely inhibited than in single conditional Ctnnb1 mutants

craniofacial
craniofacial phenotype ( J:112462 )
N
• exhibit normal posterior skull formation

limbs/digits/tail
abnormal elbow joint morphology ( J:112462 )
• the elbow joint interzone fails to form




Genotype
MGI:3687748
cn2
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased chondrocyte apoptosis ( J:112462 )
• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

skeleton
increased chondrocyte apoptosis ( J:112462 )
• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5
abnormal perichondrium morphology ( J:112462 )
• perichondrium is thinner
decreased bone mineralization ( J:112462 )
• mineralization is decreased
failure of bone ossification ( J:112462 )
• ossification is inhibited




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory