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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Polid
polymerase iota deficient
MGI:3055735
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Polid/Polid B6.129-Polid MGI:3691211
cx2
Polhtm2Fmh/Polhtm2Fmh
Polid/Polid
B6.129-Polhtm2Fmh Polid MGI:3691209
cx3
Polhtm2Fmh/Polhtm2Fmh
Polid/Poli+
B6.129-Polhtm2Fmh Polid MGI:3691210
cx4
Polhtm1Crey/Polhtm1Crey
Polid/Polid
involves: 129P2/OlaHsd * C57BL/6 MGI:3579249
cx5
Polid/Polid
Polktm1Hohm/Polktm1Hohm
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3623967


Genotype
MGI:3691211
hm1
Allelic
Composition
Polid/Polid
Genetic
Background
B6.129-Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polid mutation (3 available); any Poli mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• no difference in numbers of epithelial tumors induced by UV-B irradiation compared to wild-type mice




Genotype
MGI:3691209
cx2
Allelic
Composition
Polhtm2Fmh/Polhtm2Fmh
Polid/Polid
Genetic
Background
B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (30 available)
Polid mutation (3 available); any Poli mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Genotype
MGI:3691210
cx3
Allelic
Composition
Polhtm2Fmh/Polhtm2Fmh
Polid/Poli+
Genetic
Background
B6.129-Polhtm2Fmh Polid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (30 available)
Polid mutation (3 available); any Poli mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors appear 4 weeks earlier than in mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli




Genotype
MGI:3579249
cx4
Allelic
Composition
Polhtm1Crey/Polhtm1Crey
Polid/Polid
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm1Crey mutation (2 available); any Polh mutation (30 available)
Polid mutation (3 available); any Poli mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no B cell anomalies were observed
• Ig sequences from mutant mice PNA highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

hematopoietic system
• no B cell anomalies were observed
• Ig sequences from mutant mice PNA highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients




Genotype
MGI:3623967
cx5
Allelic
Composition
Polid/Polid
Polktm1Hohm/Polktm1Hohm
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polid mutation (3 available); any Poli mutation (35 available)
Polktm1Hohm mutation (0 available); any Polk mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• exhibit normal immunoglobulin gene somatic hypermutation and normal B and T cell populations





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory