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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CD8aCD8b)57Scr
transgene insertion 57, The Scripps Research Institute
MGI:3055355
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(B2M)55Hpl/?
Tg(CD8aCD8b)57Scr/?
Tg(HLA-B)22Hpl/?
involves: C57BL/6 * C57BL/LiA * CBA MGI:3835121
tg2
Tg(CD8aCD8b)57Scr/? B6;SJL-Tg(CD8aCD8b)57Scr/J MGI:3835111


Genotype
MGI:3835121
cx1
Allelic
Composition
Tg(B2M)55Hpl/?
Tg(CD8aCD8b)57Scr/?
Tg(HLA-B)22Hpl/?
Genetic
Background
involves: C57BL/6 * C57BL/LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(B2M)55Hpl mutation (6 available)
Tg(CD8aCD8b)57Scr mutation (1 available)
Tg(HLA-B)22Hpl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27
• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M-8) peptide concentrations
• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype

hematopoietic system
• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27
• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M-8) peptide concentrations
• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype




Genotype
MGI:3835111
tg2
Allelic
Composition
Tg(CD8aCD8b)57Scr/?
Genetic
Background
B6;SJL-Tg(CD8aCD8b)57Scr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD8aCD8b)57Scr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 8-9% of splenocytes express human CD8alpha
• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers
• either CD4+ or CD8+ T cells can express the human CD8 complex in the periphery
• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes
• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes
• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC

hematopoietic system
• 8-9% of splenocytes express human CD8alpha
• about 80% express human CD8alphaCD8beta heterodimers while about 20% express CD8alpha-alpha homodimers
• either CD4+ or CD8+ T cells can express the human CD8 complex in the periphery
• expression of human CD8 allows for effector cell function against target cells presenting viral peptide on human HLA-A2 complexes
• this cytolytic effector function is primarily carried out by T cells expressing both mouse and human CD8 complexes
• the presence of the human CD8 co-receptor does not interfere with the ability of T cells to recognize mouse MHC





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory