Analysis Tools
embryo
 N |
• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father
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Allele Symbol Allele Name Allele ID |
Tg(CAG-EGFP)D4Nagy transgene insertion D4, Andras Nagy MGI:3055027 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hemizygous males fail to gastrulate when mutant and cre are derived from the mother and the reporter is derived from the father
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, the relative volume of abnormal heart tissue begins to decline to 42% in ventricles and 47% in atria and is further reduced at E16.5 to 18% in ventricles and 19% in the atria then 10% in ventricles and 17% in the atria prior to birth
• at E12.5 and E13.5, cardiomyocytes appear small and round compared to wild-type cells
• however, the absolute volume of heart tissue before birth is unchanged
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• cardiomyocytes appear smaller at E12.5 and E13.5
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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• while the number of affected cardiomyocytes decreases proliferation of normal cardiomyocytes increases in a compensatory manner
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when the allele is maternally inherited, mice exhibit secondary non-random X inactivation compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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