About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf8tm1Pod
targeted mutation 1, Eckhard Podack
MGI:3054968
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf8tm1Pod/Tnfsf8tm1Pod B6.129X1-Tnfsf8tm1Pod MGI:3055175


Genotype
MGI:3055175
hm1
Allelic
Composition		 Tnfsf8tm1Pod/Tnfsf8tm1Pod
Genetic
Background		 B6.129X1-Tnfsf8tm1Pod
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf8tm1Pod mutation (1 available); any Tnfsf8 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to graft versus host disease ( J:92723 )
• increased host survival and decreased weight loss are seen after transplant of 1x106 fully allogeneic BALB/c CD4+ T cells into lethally irradiated homozygous mutant mice compared to wild-type mice
• no difference in survival is seen at higher CD4+ T cell concentration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory