• total B and T cells are increased by about 50%

• CD138+B220+ plasma cells are increased in 10 month old female mutants

• total B and T cells are increased by about 50%

• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants

• lymphocyte hyperproliferation, with lymphocytes exhibiting enhanced S phase entry after stimulation

• primary B cells exhibit accelearated S phase entry after stimulation

• primary T cells exhibit accelerated S phase entry after stimulation

• aged mice exhibit a 2-fold increase in serum IgG compared to wild-type mice

• deposits of IgG and C3 in the kidney

• aged mice exhibit high titers of antibodies to dsDNA

• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months

• mutants develop B220+CD19+ diffuse large B cell lymphomas

• about 30% of mutants develop B cell lymphomas in peripheral lymph nodes and spleen at 1 year of age

• lymphomas are IgM+, IgD+, CD21+, CD23+, and mature B cell type; progressed lymphomas often lose these markers

• lymphomas are monoclonal or oligoclonal in origin

• B cell lymphomas are not related to severity of autoimmune phenotypes

• mutants develop lung adenocarcinomas after 1.5 years of age

• mutants develop hepatocellular carcinomas after 1.5 years of age

• primary B cells exhibit accelearated S phase entry after stimulation

• primary T cells exhibit accelerated S phase entry after stimulation

• total B and T cells are increased by about 50%

• CD138+B220+ plasma cells are increased in 10 month old female mutants

• total B and T cells are increased by about 50%

• CD44+CD62L- effector-memory T cells are increased in 10 month old female mutants

• females exhibit evidence of glomerulonephritis by 10 months of age while males show similar phenotypes at a later age of 15-18 months

• primary B cells exhibit accelearated S phase entry after stimulation

• primary T cells exhibit accelerated S phase entry after stimulation

• impairment of B cell maturation

• defective trafficking of B cells into spleen

• increased number of immature B cells in blood

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

• reciprocal increase in T and B cells in splenic red pulp

• decrease in double positive CD4+ CD8+ cells

• increase in single positive CD4+ and CD8+ cells

• cellular migration out of thymus is 10% of wildtype

• boundary of cortex and medulla ambiguous

• spotty appearance of medulla

• impairment of B cell maturation

• defective trafficking of B cells into spleen

• increased number of immature B cells in blood

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

• defective chemokine-triggered lymphocyte adhesion and migration

• reciprocal increase in T and B cells in splenic red pulp

• decrease in double positive CD4+ CD8+ cells

• increase in single positive CD4+ and CD8+ cells

• cellular migration out of thymus is 10% of wildtype

• boundary of cortex and medulla ambiguous

• spotty appearance of medulla

• total lymphocyte numbers in peripheral lymph nodes are decreased to one half of wild-type

• decrease in size and cellular density of B cell follicles and T cell zones

• reduced numbers of CD11c+ (Itgax) dendritic cells in spleen

• following activation, dermal and splenic dendritic cells fail to migrate to draining lymph nodes and white pulp

• impairment of B cell maturation

• defective trafficking of B cells into spleen

• increased number of immature B cells in blood

• total thymocyte numbers decreased 50-60% in 7-9 week old mice

• defective chemokine-triggered lymphocyte adhesion and migration

• total lymphocyte numbers in peripheral lymph nodes are decreased to one third of wild-type

• development of glomerulonephritis that is observed in single Rassf5 homozygotes is suppressed, in addition, CD138+B220+ plasma cells are reduced by 67%, CD44+CD62L- effector-memory T cells are reduced by 28%, and titers of antibodies to dsDNA are decreased by 58% compared to single Rassf5 homozygotes and deposition of IgG in the kidney is rarely detected compared to single Rassf5 homozygotes (J:168749)

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

• mutants do not develop B cell lymphomas or other tumors (J:168749)