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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SREBP1a)7343Reh
transgene insertion 7343, Robert E Hammer
MGI:3054654
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Lcattm1Hgc/Lcattm1Hgc
Tg(SREBP1a)7343Reh/?
involves: 129 * C57BL/6 * C57BL/6J * SJL MGI:4358712
tg2
Tg(SREBP1a)7343Reh/0 B6.Cg-Tg(SREBP1a)7343Reh MGI:3801479
tg3
Tg(SREBP1a)7343Reh/0 involves: C57BL/6J * SJL/J MGI:3801474
tg4
Tg(SREBP1a)7343Reh/0 Not Specified MGI:3801483
tg5
Tg(SREBP1a)7343Reh/? involves: 129 * C57BL/6 * C57BL/6J * SJL MGI:4358714


Genotype
MGI:4358712
cx1
Allelic
Composition
Lcattm1Hgc/Lcattm1Hgc
Tg(SREBP1a)7343Reh/?
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcattm1Hgc mutation (0 available); any Lcat mutation (18 available)
Tg(SREBP1a)7343Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

homeostasis/metabolism
• the VLDL sized particles are largely devoid of triglycerides and highly enriched for free cholesterol and phospholipids
• non-HDL fractions are dominated by large sized, irregularly shaped vesicles that are not seen in transgenic mice wild-type for Lcat
• severely reduced similar to what is seen in Lcat single mutants
• decrease in the LDL/IDL fractions compared to transgenic mice wild-type for Lcat
• increase in free cholesterol levels
• increase is largely concentrated in the large VLDL fractions
• accumulation of cholesterol in the large VLDL sized fractions
• increase is largely concentrated in the large VLDL fractions
• near absence of plasma triglycerides
• present in double mutants but not in transgenic mice wild-type for Lcat

renal/urinary system
• present in double mutants but not in transgenic mice wild-type for Lcat
• at 10 months of age several podocytes are seen that contain osmiophilic inclusions
• associated with the presence of adjacent osmiophilic inclusions
• about 25% of glomeruli show segmental foam cell infiltrates which preferentially involve the glomerular vascular poles in 60% of the cases
• many glomerular capillary loops show decreased patency due to mesangial encroachment
• diffuse glomerular arteriolar hyalinosis is detected
• at 10 months of age, large focal accumulations of neutral lipids are seen in more than 50% of the glomeruli
• from 6 to 10 months of age mice show progression with fewer lipid deposits and evidence of chronic mesangial injury
• many glomerular capillary loops show decreased patency due to mesangial encroachment
• mice with foam cell infiltrates also show a diffuse mild to moderate and focally marked increase in mesangial cellularity, occasionally forming mesangial nodules
• mice with foam cell infiltrates also show diffuse moderate increases in mesangial matrix
• at 10 months of age several foci of mesangial hyalinosis are seen
• from 6 to 10 months of age mice display progressive glomerulosclerosis
• ultrastructural evidence of tubulointerstitial accumulation of lipid deposits is seen at 10 months of age
• some proximal tubule epithelial cells contain intracellular protein re-absorption droplets
• osmiophilic inclusions are seen in proximal tubule epithelial cell adjacent to the basement membrane and in the cortical interstitium

liver/biliary system

cardiovascular system
• many glomerular capillary loops show decreased patency due to mesangial encroachment




Genotype
MGI:3801479
tg2
Allelic
Composition
Tg(SREBP1a)7343Reh/0
Genetic
Background
B6.Cg-Tg(SREBP1a)7343Reh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SREBP1a)7343Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• despite peripheral insulin resistance, mice exhibit normal non-esterified fatty acid levels in the plasma and do not develop diabetes
• fasting glucose levels are slightly higher than in wild-type mice
• when fed ad libitum and following glucose loading, mice exhibit increased circulating insulin levels
• mice exhibit postprandial hyperinsulinemia
• mice exhibit peripheral insulin resistance

endocrine/exocrine glands
• beta cell mass is increased 3-fold compared to in wild-type mice

liver/biliary system

adipose tissue
• lipodystrophy (loss and abnormal redistribution of body fat)

growth/size/body




Genotype
MGI:3801474
tg3
Allelic
Composition
Tg(SREBP1a)7343Reh/0
Genetic
Background
involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SREBP1a)7343Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after birth, mice exhibit abdominal swelling due to an enlarged liver than continues to enlarge after weaning when mice are placed on a low carbohydrate/high protein diet
• liver enlargement occurs due to increased lipid accumulation
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver weight is increased 4-fold compared to similarly treated wild-type mice

homeostasis/metabolism
N
• despite increases in liver lipid synthesis and content after being fed a low carbohydrate/high protein diet for 2 weeks, mice exhibit normal plasma glucose, creatinine, alkaline phophatase, bilirubin, and blood urea nitrogen levels
• lipid biosynthesis is increased compared to in wild-type mice
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver cholesterol levels are increased 4.7-fold compared to in wild-type mice
• however, plasma cholesterol levels are normal
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver triglyceride levels are increased 21-fold compared to in wild-type mice

liver/biliary system
N
• despite accumulation of fat in the liver, mice do not exhibit generalized inflammation in the liver or liver necrosis
• after birth, mice exhibit abdominal swelling due to an enlarged liver than continues to enlarge after weaning when mice are placed on a low carbohydrate/high protein diet
• liver enlargement occurs due to increased lipid accumulation
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver weight is increased 4-fold compared to similarly treated wild-type mice
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver cholesterol levels are increased 4.7-fold compared to in wild-type mice
• however, plasma cholesterol levels are normal
• after being fed a low carbohydrate/high protein diet for 2 weeks, liver triglyceride levels are increased 21-fold compared to in wild-type mice
• at 16 weeks of age mice exhibit distended hepatocytes due to fat droplet accumulation

adipose tissue
• mice exhibit a decrease in subcutaneous, omental, perirenal and epididymal fat compared to in wild-type mice
• after being fed a low carbohydrate/high protein diet for 2 weeks, epididymal fat pad weight is decreased by more than 90% compared to similarly treated wild-type mice




Genotype
MGI:3801483
tg4
Allelic
Composition
Tg(SREBP1a)7343Reh/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SREBP1a)7343Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• after 70% resection, liver regeneration is suppressed due to decreased proliferation compared to in wild-type mice




Genotype
MGI:4358714
tg5
Allelic
Composition
Tg(SREBP1a)7343Reh/?
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SREBP1a)7343Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

homeostasis/metabolism
• significant reduction in cholesterol in all lipoprotein fractions
• decrease in total cholesterol in the plasma
• decrease in total cholesterol is largely the result of a decrease in HDL cholesterol

renal/urinary system
N
• unlike transgenic mice that are also null for Lcat, no significant ultrastructural kidney abnormalities are detected
• occasional foci of mild arteriolar hyalinosis
• occasional foci of mild mesangial hypercellularity are seen
• focal mild mesangial matrix expansion

liver/biliary system





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory