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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gli1tm3(cre/ERT2)Alj
targeted mutation 3, Alexandra L Joyner
MGI:3053957
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4461250
cn2
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tnntm1b(KOMP)Wtsi/Tnntm1b(KOMP)Wtsi
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N MGI:6694853
cn3
Gt(ROSA)26Sortm2(HOXC9)Odk/Gt(ROSA)26Sortm2(HOXC9)Odk
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129S6/SvEvTac MGI:5695620
cn4
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * 129X1/SvJ MGI:6197800
cn5
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
involves: 129S6/SvEvTac * 129X1/SvJ MGI:3810320
cn6
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129S6/SvEvTac * 129X1/SvJ MGI:4461251
cn7
Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster MGI:7531280
cn8
Artm2Ska/Y
Gli1tm3(cre/ERT2)Alj/Gli1+
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4461249


Genotype
MGI:4461250
cn1
Allelic
Composition
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation (1 available); any Ctnnb1 mutation (49 available)
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice
• however, development of female genital tracts is normal
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice

renal/urinary system
• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice




Genotype
MGI:6694853
cn2
Allelic
Composition
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tnntm1b(KOMP)Wtsi/Tnntm1b(KOMP)Wtsi
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (935 available)
Tnntm1b(KOMP)Wtsi mutation (0 available); any Tnn mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

growth/size/body
• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced

skeleton
• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced




Genotype
MGI:5695620
cn3
Allelic
Composition
Gt(ROSA)26Sortm2(HOXC9)Odk/Gt(ROSA)26Sortm2(HOXC9)Odk
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Gt(ROSA)26Sortm2(HOXC9)Odk mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• size of the labial cervical loop at the proximal end of the incisor is not affected after tamoxifen injection




Genotype
MGI:6197800
cn4
Allelic
Composition
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• tamoxifen-treated mice do not exhibit distal airspace morphological changes




Genotype
MGI:3810320
cn5
Allelic
Composition
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice survive 45 days

neoplasm
• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days

nervous system
• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days




Genotype
MGI:4461251
cn6
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• female tamoxifen-treated mice exhibit well-developed prepuce unlike wild-type female mice
• adult tamoxifen-treated mice exhibit a hyperplasic prepuce with enlarged external genitalia similar to male mice unlike wild-type female mice
• however, the scrotal/perineal region is normal




Genotype
MGI:7531280
cn7
Allelic
Composition
Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster
Cell Lines EPD0746_4_G08
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
Slfn4tm1c(EUCOMM)Wtsi mutation (0 available); any Slfn4 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H+, K+ -ATPase+ parietal cells

immune system
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls
• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls

homeostasis/metabolism
• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls

hematopoietic system
• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls




Genotype
MGI:4461249
cn8
Allelic
Composition
Artm2Ska/Y
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm2Ska mutation (0 available); any Ar mutation (22 available)
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice
• external genitalis of tamoxifen-treated mice are feminized
• underdeveloped in tamoxifen-treated mice
• prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice
• however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system
• underdeveloped in tamoxifen-treated mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory