Phenotypes associated with this allele
reproductive system
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce and ventral midline formation unlike wild-type mice
• however, development of female genital tracts is normal
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice
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renal/urinary system
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• 40% of tamoxifen-treated male mice fail to develop a proper prepuce unlike wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation
(10 available);
any
Gt(ROSA)26Sor mutation
(935 available)
Tnntm1b(KOMP)Wtsi mutation
(0 available);
any
Tnn mutation
(91 available)
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craniofacial
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• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced
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growth/size/body
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• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced
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skeleton
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• after tamoxifen injection, lineage tracing experiments revealed differentiation and proliferation defects in the incisor stem cell compartment at 3 months of age
• GFP+ Gli1 expressing cells are decreased in number and in area in the incisor pulp, indicating decreased hedgehog signaling
• Ki67 immunostaining showed that the proliferation rate of putative mesenchymal stem cells is reduced
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
Gt(ROSA)26Sortm2(HOXC9)Odk mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(935 available)
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craniofacial
N |
• size of the labial cervical loop at the proximal end of the incisor is not affected after tamoxifen injection
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(935 available)
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respiratory system
N |
• tamoxifen-treated mice do not exhibit distal airspace morphological changes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(935 available)
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mortality/aging
neoplasm
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• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days
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nervous system
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• all mice develop medulloblastomas that are located in lobes VI through IX and have a mean survival of 45 days
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
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reproductive system
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• female tamoxifen-treated mice exhibit well-developed prepuce unlike wild-type female mice
• adult tamoxifen-treated mice exhibit a hyperplasic prepuce with enlarged external genitalia similar to male mice unlike wild-type female mice
• however, the scrotal/perineal region is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
Slfn4tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Slfn4 mutation
(34 available)
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digestive/alimentary system
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• at 4 months after inoculation with Helicobacter felis (H. felis), tamoxifen-treated mice develop significantly less Helicobacter-induced spasmolytic polypeptide-expressing metaplasia (SPEM) than 4-month-infected wild-type controls, as shown by reduced GSII-lectin staining and recovery of some H+, K+ -ATPase+ parietal cells
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immune system
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• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls
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• H. felis-infected tamoxifen-treated mice show decreased gastric interleukin-1 alpha (IL1a) levels relative to infected controls
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• H. felis-infected tamoxifen-treated mice show decreased gastric TNF levels relative to infected controls
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• H. felis-infected tamoxifen-treated mice show attenuated Helicobacter-induced gastric metaplasia relative to infected wild-type controls
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homeostasis/metabolism
hematopoietic system
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• H. felis-infected tamoxifen-treated mice show an increased population of CD8+ cytotoxic T cells in the stomach relative to infected wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm2Ska mutation
(0 available);
any
Ar mutation
(22 available)
Gli1tm3(cre/ERT2)Alj mutation
(2 available);
any
Gli1 mutation
(48 available)
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reproductive system
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• tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice
• external genitalis of tamoxifen-treated mice are feminized
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• underdeveloped in tamoxifen-treated mice
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• prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice
• however, development of internal reproductive organs are normally in tamoxifen-treated mice
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renal/urinary system
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• underdeveloped in tamoxifen-treated mice
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