mortality/aging
• homozygous mutants die from pulmonary metastases after injection of melanoma cells earlier compared to wild-type mice
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neoplasm
• average tumor size and number of metastases are increased after injection of melanoma cells compared to wild-type mice
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integument
• the number of large collagen fibrils is increased and the number of small diameter collagen fibrils does not increase with age resulting in an increase in the average size of collagen fibrils in the skin of mutants
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