All Phenotypes Tnfrsf1a<tm1.1Gkl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnfrsf1a^tm1.1Gkl
targeted mutation 1.1, George Kollias
MGI:3053140

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129/Sv * C57BL/6	MGI:3053727
ht2	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a⁺	involves: 129/Sv * C57BL/6	MGI:3053732
cx3	Tg(TNF)197Gkl/0 Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129 * C57BL/6 * CBA	MGI:3053722
cx4	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129S/SvEv * C57BL/6	MGI:3053734
cx5	Rag1^tm1Bal/Rag1^tm1Bal Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129/Sv * C57BL/6	MGI:3053736
cx6	Fas^lpr/Fas^lpr Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129/Sv * C57BL/6	MGI:3053737
cx7	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm	involves: 129/Sv * C57BL/6	MGI:3053739

Allelic Composition	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:92470 )

• intravenous injection of recombinant human TNF resulted in lethality in all homozygotes compared to only 11% of wild-type mice

• increased LPS induced lethality is also seen in homozygotes compared to wild-type mice

immune system

abnormal cytokine secretion ( J:92470 )

• LPS stimulated macrophages produce more TNF and NO

increased susceptibility to experimental autoimmune encephalomyelitis ( J:92470 )

• increased susceptibility to and severity of experimental autoimmune encephalomyelitis is seen

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• iver inflammation is more severe in homozygotes compared to heterozygotes

decreased susceptibility to bacterial infection ( J:92470 )

• homozygous mice can tolerate 10-fold higher doses of Listeria monocytogenes compared to wild-type mice

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• iver inflammation is more severe in homozygotes compared to heterozygotes

Allelic Composition	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:92470 )

• intravenous injection of recombinant human TNF resulted in lethality in 71% of heterozygotes compared to only 11% of wild-type mice

• increased LPS induced lethality is also seen in heterozygotes compared to wild-type mice

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• liver inflammation is less severe in heterozygotes compared to homozygotes

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• liver inflammation is less severe in heterozygotes compared to homozygotes

Allelic Composition	Tg(TNF)197Gkl/0 Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TNF)197Gkl mutation (2 available)
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arthritis ( J:92470 )

• accelerated development of arthritis is seen with earlier and more severe pannus formation, articular cartilage destruction, and bone erosion

skeleton

arthritis ( J:92470 )

• accelerated development of arthritis is seen with earlier and more severe pannus formation, articular cartilage destruction, and bone erosion

Allelic Composition	Tnf^tm1Gkl/Tnf^tm1Gkl Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)
Tnf^tm1Gkl mutation (6 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:92470 )

N	• no liver inflammation is seen unlike in Tnfrsf1a^tm1Gkl homozygotes

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

Allelic Composition	Fas^lpr/Fas^lpr Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

Allelic Composition	Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)
Tnfrsf1b^tm1Mwm mutation (2 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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