About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapk8ip3tm1Rjd
targeted mutation 1, Roger J Davis
MGI:3053053
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd B6.129S6-Mapk8ip3tm1Rjd MGI:3618380


Genotype
MGI:3618380
hm1
Allelic
Composition
Mapk8ip3tm1Rjd/Mapk8ip3tm1Rjd
Genetic
Background
B6.129S6-Mapk8ip3tm1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8ip3tm1Rjd mutation (1 available); any Mapk8ip3 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are unable to breathe and die shortly after birth

nervous system
• homozygotes may exhibit defects in neuronal growth-cone function and axon guidance, as suggested by a reduction in signal transduction by RhoA and its effector ROCK
• newborn homozygotes exhibit abnormal telencephalon morphogenesis, with a less compact zone of neurons surrounding each dilated lateral ventricle, scattered debris, absence of white matter intrahemispheric connection, and disorganized adjacent white tracts with frequent vacuoles
• mutant brains lack the telencephalic commissure, a major connection between the left and right hemispheres
• newborn homozygotes may exhibit impaired synaptic activity, as suggested by decreased expression of a number of glutamate receptor subunits and of syntaxin binding protein 1

respiratory system
• lungs from newborn homozygotes display collapsed alveolar spaces
• lungs from newborn homozygotes exhibit hypercellular alveolar septa
• newborn homozygotes fail to breathe
• when placed in PBS, dissected mutant lungs fail to inflate and float, suggesting that homozygotes fail to inflate their lungs after birth

homeostasis/metabolism
• newborn homozygotes become rapidly anoxic

cellular
• homozygotes may exhibit defects in neuronal growth-cone function and axon guidance, as suggested by a reduction in signal transduction by RhoA and its effector ROCK





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory