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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prnptm2Tuzi
targeted mutation 2, Nadia L Tuzi
MGI:3052799
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Prnptm2Tuzi/Prnp+ involves: 129P2/OlaHsd MGI:3053028
ht2
Prnptm2Tuzi/Prnptm2Edin involves: 129P2/OlaHsd MGI:3053029
cn3
Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053024
cn4
Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053025


Genotype
MGI:3053028
ht1
Allelic
Composition
Prnptm2Tuzi/Prnp+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• TSE strain ME7 incubation time is similar to wild-type mice is seen




Genotype
MGI:3053029
ht2
Allelic
Composition
Prnptm2Tuzi/Prnptm2Edin
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (150 available)
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• an increased incubation time for TSE strain ME7 compared to wild-type mice
• this incubation time is similar to that for Prnptm2Edin heterozygotes




Genotype
MGI:3053024
cn3
Allelic
Composition
Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (150 available)
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination




Genotype
MGI:3053025
cn4
Allelic
Composition
Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• an increased incubation time for TSE strain ME7 compared to wild-type mice or mutants without cre recombination is seen





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory