Analysis Tools
normal phenotype
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• mice heterozygous for this targeted reporter gene are viable, fertile and exhibit no gross physical or behavioral abnormalities
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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(Luc)Kael targeted mutation 1, William G Kaelin MGI:3052356 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice heterozygous for this targeted reporter gene are viable, fertile and exhibit no gross physical or behavioral abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit reduced survival compared with control mice
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• mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit increased tumor incidence (size and number) in the lungs with rare noninvasive lung adenomas compared with control mice
• however, mice treated with a cre-expressing adenovirus and treated with doxycycline exhibit tumor regression after doxycycline removal
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• in mice treated with a cre-expressing adenovirus and treated with doxycycline
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• in mice treated with a cre-expressing adenovirus and treated with doxycycline
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• rapid shallow breathing in mice treated with a cre-expressing adenovirus and treated with doxycycline
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• in mice treated with a cre-expressing adenovirus and treated with doxycycline
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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