All Phenotypes Socs3<tm1Ayos> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Socs3^tm1Ayos
targeted mutation 1, Akihiko Yoshimura
MGI:3051525

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Socs3^tm1Ayos/Socs3^tm1Ayos Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129 * C57BL/6	MGI:3051636
cn2	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6	MGI:3051638
cn3	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Syn1-cre)671Jxm/0	involves: 129 * C57BL/6	MGI:3051642

Allelic Composition	Socs3^tm1Ayos/Socs3^tm1Ayos Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Socs3^tm1Ayos mutation (2 available); any Socs3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:92040 )

• mutants are more resistant to LPS induced endotoxin shock

Allelic Composition	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Ayos mutation (2 available); any Socs3 mutation (21 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

behavior/neurological

abnormal food intake ( J:91796 )

• food intake is decreased on a high fat diet compared to wild-type mice on the same diet

• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice

growth/size/body

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

decreased body weight ( J:91796 )

• on a high fat diet mutants gain less weight

weight loss ( J:91796 )

• treatment with leptin induces greater weight loss in mutants

homeostasis/metabolism

decreased circulating free fatty acids level ( J:91796 )

• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants

decreased circulating triglyceride level ( J:91796 )

• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants

improved glucose tolerance ( J:91796 )

• glucose clearance is significantly faster in mutants compared to wild-type mice

increased insulin sensitivity ( J:91796 )

• on a high fat diet mutants do not develop insulin resistance

Allelic Composition	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Ayos mutation (2 available); any Socs3 mutation (21 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

behavior/neurological

abnormal food intake ( J:91796 )

• food intake is decreased on a high fat diet compared to wild-type mice on the same diet

• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice

growth/size/body

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

decreased body weight ( J:91796 )

• on a high fat diet mutants gain less weight

weight loss ( J:91796 )

• treatment with leptin induces greater weight loss in mutants

homeostasis/metabolism

decreased circulating free fatty acids level ( J:91796 )

• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants

decreased circulating triglyceride level ( J:91796 )

• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants

improved glucose tolerance ( J:91796 )

• glucose clearance is significantly faster in mutants compared to wild-type mice

increased insulin sensitivity ( J:91796 )

• on a high fat diet mutants do not develop insulin resistance

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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